Urea and thiourea derivatives of azolones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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544238, 544295, 544357, 544364, 544566, 544370, A61K 31495, A61K 3150, C07D40114, C07D40310

Patent

active

056397542

ABSTRACT:
The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; Y is CH or N; R.sup.1, R.sup.2 and R.sup.3 each independently are hydrogen or C.sub.1-4 alkyl; R.sup.4 and R.sup.5 each independently are hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R.sup.6 is C.sub.1-4 alkyl; C.sub.1-4 alkyl substituted with arylcyclohexyl; aryl or arylcarbonyl; wherein aryl is phenyl optionally substituted with one or two substituents selected from halo and C.sub.1-4 alkyl;

REFERENCES:
patent: 4791111 (1988-12-01), Heeres et al.
patent: 4931444 (1990-06-01), Van Wavwe et al.
patent: 5371101 (1994-12-01), Itoh et al.
patent: 5571811 (1996-11-01), Heeres et al.

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