Urapidil/furosemide compounds, compositions and use

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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544295, 2603472, A61K 31505, C07D40500

Patent

active

041316789

ABSTRACT:
A combination of urapidil and furosemide, e.g., in the form of an acid-addition salt, in the form of a physical admixture or in the form of two distinct components collectively constitutes an effective active ingredient in the treatment of hypertension. The combination is advantageously incorporated in a standard dosage form and administered by various routes to mammals afflicted with high blood pressure. By combining furosemide with urapidil on one of the noted forms, the maximum hypotensive activity of urapidil is increased, while the side effects and toxicity of urapidil are reduced.

REFERENCES:
patent: 3058882 (1962-10-01), Sturm et al.
patent: 3957786 (1976-05-01), Klemm et al.

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