Uracil derivatives as inhibitors of TNF-α converting...

Details Uracil derivatives as inhibitors of TNF-α converting... Uracil derivatives as inhibitors of TNF-α converting...

2006-09-05

2006-09-05

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S224000, C544S242000

Reexamination Certificate

active

07101883

ABSTRACT:
The present application describes novel uracil derivatives of formula I:in-line-formulae description="In-line Formulae" end="lead"?A-W-U-X-Y-Z-Ua-Xa-Ya-ZaIin-line-formulae description="In-line Formulae" end="tail"?or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, W, U, X, Y, Z, Ua, Xa, Ya, and Zaare defined in the present specification, which are useful as inhibitors of TNF-α converting enzyme (TACE), matrix metalloproteinases (MMP), aggrecanase or a combination thereof.

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