Uracil derivatives and production thereof

Details Uracil derivatives and production thereof Uracil derivatives and production thereof

1978-09-22

1980-02-26

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260566AE, 542416, 544300, 544301, C07D23910

Patent

active

041906560

ABSTRACT:
New compounds of the formula ##STR1## (wherein R.sub.1 represents a lower alkyl group: and ##STR2## represents an alkylidene radical in which at least one of R.sub.2 and R.sub.3 is a lower alkyl which may optionally be substituted by phenyl, phenyl or a 5- or 6-membered aromatic ring including S, N or O, and the remainder, if any, is hydrogen; or
a cycloalkylidene radical of up to six carbon atoms, to which a benzene ring may optionally be fused).
These compounds are produced by reacting the corresponding 6-acyloxy compounds with a compound of the formula ##STR3## The new compounds have antiviral activity and are useful to prolong the life spans of tumor-bearing animals.

REFERENCES:
patent: 3360523 (1967-12-01), Loux
patent: 3466280 (1969-09-01), Loux
patent: 3775406 (1973-11-01), Trueb
patent: 3954758 (1976-05-01), Schuman et al.
patent: 3954759 (1976-05-01), Anderson et al.
patent: 3987045 (1976-10-01), Bock et al.
patent: 4017626 (1977-04-01), Gauri
patent: 4071519 (1978-01-01), Ozaki et al.
patent: 4080455 (1978-03-01), Yasumoto et al.
patent: 4088646 (1978-05-01), Ishida et al.
Johnson et al., J. Am. Chem. Soc. 55 (1933), pp. 3871-3873.

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