Uracil derivatives and production thereof

Details Uracil derivatives and production thereof Uracil derivatives and production thereof

1979-06-13

1982-05-11

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

42424854, 42424855, 424251, 424254, 544123, 544229, 544302, 544303, 544311, 544314, 544317, A61K 31515, C07D23922, C07D40104, C07D40106

Patent

active

043294600

ABSTRACT:
New derivatives of the formula: ##STR1## (wherein X is O or NH; R.sub.1 is --OH which may optionally be etherified or esterified, etherified mercapto or --NH.sub.2 which may optionally be substituted; R.sub.2 and R.sub.3, respectively, mean H, lower alkyl or ##STR2## and Y is an esterified or amidated carboxyl group, or CN). These derivatives are produced, by fluorination of corresponding 1,2,3,4-tetrahydro-2,4-dioxopyrimidine compounds and can be converted into 5-fluorouracil derivatives under hydrolytic conditions. The new derivatives are able to prolong the lives of animals having carcinomas or have antiviral activity.

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