Uracil derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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Details

544 8, 5142225, 514252, 514254, C07D40312, C07D41712, A61K 31505

Patent

active

060463295

ABSTRACT:
Compounds of formula I, in which the substituents and symbols have the meanings indicated in the description, R5-HT.sub.1A -agonists and .alpha..sub.1 -adrenoceptor blockers. Compositions containing these compounds as active ingredients are useful for treating those diseases which can be treated by 5-HT.sub.1A agonists or by .alpha..sub.1 -adrenoreceptor blockers.

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Hoffman, "Adrenoceptor-Blocking Drugs," Basic & Clinical Pharmacology, 6th edition, Chapter 10, pp. 132-141, 1995.
Zech et al., "Determination of Urapidil and Its Metabolites in Human Serum and Urine: Comparison of Liquid-Liquid and Fully Automated Liquid-Solid Extraction," Journal of Chromatography, 353, pp. 351-360, 1986.
Zech et al., "Biotransformation of Urapidil: Metabolites in Serum and Urine and their Biological Activity in vitro and in vivo," Arch. Internationales de Pharmacodynamie et de Therapie, 272, No. 1, pp. 180-196, 1984.
Caine, "Alpha-Adrenergic Mechanisms in Dynamics of Benign Prostatic Hypertrophy," Supplement to Urology, vol. 32, No. 6, pp. 16-20, 1988.

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