Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1997-07-02
1999-04-06
Housel, James C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 721, 422 56, 422 8208, G01N 3353
Patent
active
058916563
ABSTRACT:
The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.
REFERENCES:
patent: 3593055 (1971-07-01), Geusinc et al.
patent: 3599109 (1971-08-01), Guggenheim et al.
patent: 3634614 (1972-01-01), Geusic et al.
patent: 4032351 (1977-06-01), Auzel et al.
patent: 4100416 (1978-07-01), Hirshfeld et al.
patent: 4206132 (1980-06-01), Sievers
patent: 4228237 (1980-10-01), Hevey et al.
patent: 4492751 (1985-01-01), Boguslaski et al.
patent: 4666862 (1987-05-01), Chang
patent: 4695393 (1987-09-01), Whitehead et al.
patent: 4710635 (1987-12-01), Chupp
patent: 4724217 (1988-02-01), Miller et al.
patent: 4727020 (1988-02-01), Recktenwald
patent: 4837169 (1989-06-01), Toner
patent: 4905169 (1990-02-01), Buican et al.
patent: 4913883 (1990-04-01), Imai et al.
patent: 4983359 (1991-01-01), Tomioka et al.
patent: 5043265 (1991-08-01), Tanke et al.
patent: 5066580 (1991-11-01), Lee et al.
patent: 5132242 (1992-07-01), Cheung
patent: 5141740 (1992-08-01), Rajagopalan et al.
patent: 5166948 (1992-11-01), Gavrilovic et al.
patent: 5185265 (1993-02-01), Steen et al.
patent: 5188942 (1993-02-01), Reddington et al.
patent: 5196709 (1993-03-01), Berndt et al.
patent: 5208651 (1993-05-01), Buican
patent: 5247339 (1993-09-01), Ogino
patent: 5324633 (1994-06-01), Fodor et al.
patent: 5399315 (1995-03-01), Paz-Pujalt et al.
patent: 5436170 (1995-07-01), Cornell et al.
patent: 5443955 (1995-08-01), Cornell et al.
patent: 5514337 (1996-05-01), Groger et al.
patent: 5599578 (1997-02-01), Butland
patent: 5674698 (1997-10-01), Zarling et al.
Evangelista et al., "Enzyme-amplified Lanthanide Luminescence for Enzyme Detection in Bioanalytical Assays," Anal.Biol. (1991) 137:213-224.
Hemmila et al., "Europium as a Label in Time-resolved Immunofluorometric Assays," Anal.Biol. (1984) 137:335-343.
Lovgren et al., "Detection of Lanthanide Chelates by Time-resolved Fluorescence, in Nonisotopic Dna Probe Techniques" Academic Press (1992) 227-261.
Mukkala et al., "The Synthesis and Use of Activate N-benzyl Derivatives of Diethylenetriaminetetraacetic Acids: Alternative Reagents for Labeling of Antibodies with Metal Ions," Anal. Bio. (1989) 176:319-325.
P.A. Santa Cruz, et al., "Quim, Nova" (1983) 6:149-151). (Spanish article)-Title in English.
Voller, "The Enzyme Linked Immunosorbent Assay (ELISA),"in Diagnostic Horizons,(1978) 2:1:1-7.
Beverloo et al., "Preparation and microscopic visualization of multicolor luminescent immunophosphors", Cytometry (1992) 13:561-570.
B.J. Tromberg et al. "Proc. SPIE-INT" Soc. Opt. Eng., (1991) 1427:101-108.
D.C. Yeh et al., "J. Appl. Phys"., (1988) 63:4644-4650.
D.C. Yeh et al., "Phys. Rev. B", (1989) 39:80-90.
D.R. Tallant et al., J. Chem. Phys., (1975) 63:2074-2085.
Wojciechowski, et al., "Infrared-to-Blue Up-converting Phosphor", Electron Technology (1978) 11:3:31-47.
Moser, K., et al., "Infrared Spectral Distribution of Photoconductivity and Up-conversion in GaP Light Emitting Diodes", J. Appl Phys, (1985) 57:12:5438-5442.
Tanabe, S., et al., "Up-conversion Fluorescences of TeO.sub.2 - and Ga.sub.2 O.sub.3 - Based Oxide Glasses Containing Er.sup.3+ ", Journal of Non-Crystalline Solids, (1990) 122:79-82.
Allain et al., "Room Temperature CW Tunable Green Upconversion Holmium Fibre Laser," Electronics Letters (1990) 26:261-263.
Allain et al., "Blue Upconversion Fluorozirconate Fibre Laser", Electronic Letters, (1990) 26:166-168.
Auzel, "Materials and Devices Using Double-pumped Phosphors and Energy Transfer", Proceedings of the IEEE (1973) 61:758-786.
Berthou and Jorgensen "Optical-fibre temperature sensor based on upconversion-excited fluorescence", Optic Letters (1990) 15:1100-1102.
Bethune et al., "Atoms in carbon cages: the structure and properties of endohedral fullerences", Nature (1993) 366:123-128.
Beverloo et al., "Inorganic phosphors as new luminscent labels for immunocytochemistry and time-resolved microscopy", Cytometry (1990) 11:784-792.
Camus et al., "Two-photon absorption spectroscopy in ytterbium", J. Phys. B: Atom. Molec. Phys. (1978) 11:L395-L397.
Campiglia, A.D. et al., "Utilization of an Inorganic Phosphor as a Reference Signal in Solid- Surface Room Temperature Phosphorimetry", Anal. Chem. (1988) vol. 60(g):2165-2167.
Diamandis and Christopoulos, Detection of Lanthanide Chelates and Multiple Labeling Strategies Based on Time-resolved Fluorescence, in Nonisotopic DNA Probe Techniques, Academic Press (1992) 263-274.
Eichstein et al., "Laser-excited Time-resolved Solid-phase Fluoroimmunoassays with the New Europium Chelate 4, 7-bis (chlorosulfophenyl)-1, 10-phenanthroline-2, 9-dicarboxylic Acid as Label," Anal. Chem. (1988) 60:1069-1074.
Gudgin Templeton et al., "Time Resolved Fluorescence Detection of Enzyme-amplified Lanthanide Luminescence for Nucleic Acid Hybridization Assays," Clin. Chem. (1991) 37/9:1509-1512.
Johnson et al., "Infrared-to-visible Conversion by Rare-earth Ions in Crystals," J. Appl Phys. (1972) 43:3.
Johnston and Wright, "Trace Analysis of Nonfluorescent Ions by Associate Clustering with a Fluorescent Probe," Anal. Chem. (1979) 51:1774-1780.
Kano et al., NaLnF.sub.4 :YB.sup.3+,(Ln:Y,Gd,La): Efficient Green-emitting Infrared-excited Phosphors, J. Electrochem. Soc. (1972) 119:1561-1564.
Leif and Vallarino, "Rare-earth Chelates as Fluorescent Marks in Cell Separation and Analysis," Cell Separation Science and Technology (1991) 3:41-58.
Lenth and Macfarlane, Lasers, Optics & Photonics News, (1992) 3:8-15.
Louge et al., "Optical Fiber Measurements of Particle Velocity Using Laser-induced Phosphorescence," Applied Optics (1991) 30:1976-1981.
Manashirov et al., "Effect of the Purity of Initial Substances on Luminescence Intensity of Erbium in Anti-stroke Luminophores," Chemical Abstracts, (1989) 110:457 Abstract No. 30750B.
McFarlane, "Dual Wavelength Visible Upconversion Laser," Appl. Phys. Letts. (1989) 54:2301-2302.
McFarlane, "Violet Cw Neodymium Upconversion Laser," Appl. Phys. Letts. (1988) 54:1300-1302.
Nguyen et al., "Blue-green (450-nm) Upconversion Tm.sup.3+ :Ylf Laser," Applied Optics (1989) 28:3553-3555.
Rich and Pinow, Exploring the Ultimate Efficiency in Infrared-to-Visible Coverting Phosphors Activated with Er and Sensitized with Yb, J. Appl. Phys. (1972) 43:2357-2365.
Schindele and Renzoni, "Ultra Fluors: New Fluorophores for Immunological Applications", J. Clin. Immun. (1990) 13:182-186.
Seveus et al., "Time-Resolved Fluorescence Imaging of Europium chelate Label in Immunochistochemistry and in Situ Hybridization," Cytometry (1992) 13:329-338.
Silversmith et al., "Green Infrared-Pumped Erbium Upconversion Laser," J. Opt. Soc. Am. (1982) 3:128-12.
Soini and Kojola,"Time-resolved Fluorometer for Lanthanide Cachelates--a New Generation of Nonisotopic Immunoassays,"Clin Chem. (1983) 29/1:65-68.
Soules and Hoffman, "Luminescent Materials (Phosphors)," Encylclopedia of Chemical Technology, (1981) Third Edition, 14:527-545.
Tiffany, "Fluorometry, Nephelometry, and Turbidimetry," Textbook of Clinical Chemistry, (1986) 78-90.
Xu and Hemmila, "Co-fluorescence Enhancement System Based on Pivaloyltrifluoroacetone and Yttriuim for the Simultaneous Detection of Europium, Terbium, Samarium and Dysprosium," Anal. Chimica Acta. (1992) 256:9-16.
Lovgren, J. et al, Jul. 12, 1994, J. Immunol. Methods, vol. 173(1), pp. 119-125.
Beverloo et al, Cytometry, 1992, vol. 13(6), pp. 561-570.
Lovgren, T et al, Oct. 1997, vol. 43(10) pp. 1937-1943, Clinical Chemistry.
Heinonen, Petal, Clin. Chem., 1977, 43(7), pp. 1142-1150.
Evangelista, R.A et al, Analytical Biochem., vol. 197(1), 1991, pp. 213-224.
Hemmila, I. et
Dyer Mark J.
Faris Gregory W.
Kane James
Ng Steve Y.
Peppers Norman A.
Housel James C.
Portner Ginny Allen
SRI - International
LandOfFree
Up-converting reporters for biological and other assays using la does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Up-converting reporters for biological and other assays using la, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Up-converting reporters for biological and other assays using la will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1370220