Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-01-30
2000-12-12
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 529, 435 71, 536 231, 536 243, 5303871, 530350, 2504842, 2504843, C12Q 168, C07H 2102, C07H 2104, C07K 1600, G01N 3353, H05B 3300
Patent
active
061596868
ABSTRACT:
The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.
REFERENCES:
patent: 3593055 (1971-07-01), Geusic et al.
patent: 3599109 (1971-08-01), Guggenheim et al.
patent: 3634614 (1972-01-01), Geusic et al.
patent: 4000252 (1976-12-01), Kosak
patent: 4032351 (1977-06-01), Auzel et al.
patent: 4100416 (1978-07-01), Hirshfeld et al.
patent: 4206132 (1980-06-01), Sievers
patent: 4228237 (1980-10-01), Hevey et al.
patent: 4372745 (1983-02-01), Mandle et al.
patent: 4492751 (1985-01-01), Boguslaski et al.
patent: 4604364 (1986-08-01), Kosak
patent: 4666862 (1987-05-01), Chang
patent: 4695393 (1987-09-01), Whitehead et al.
patent: 4710635 (1987-12-01), Chupp
patent: 4724217 (1988-02-01), Miller et al.
patent: 4727020 (1988-02-01), Recktenwald
patent: 4837169 (1989-06-01), Toner
patent: 4868103 (1989-09-01), Stavrianopoulos et al.
patent: 4905169 (1990-02-01), Buican et al.
patent: 4913883 (1990-04-01), Imai et al.
patent: 4983359 (1991-01-01), Tomioka et al.
patent: 5043265 (1991-08-01), Tanke et al.
patent: 5066580 (1991-11-01), Lee et al.
patent: 5102786 (1992-04-01), Cohen et al.
patent: 5132242 (1992-07-01), Cheung
patent: 5141740 (1992-08-01), Rajagopalan et al.
patent: 5166948 (1992-11-01), Gavrilovic et al.
patent: 5185265 (1993-02-01), Steen et al.
patent: 5188942 (1993-02-01), Reddington et al.
patent: 5196709 (1993-03-01), Berndt et al.
patent: 5208651 (1993-05-01), Buican
patent: 5247339 (1993-09-01), Ogino
patent: 5324633 (1994-06-01), Fodor et al.
patent: 5326692 (1994-07-01), Brinkley et al.
patent: 5399315 (1995-03-01), Paz-Pujalt et al.
patent: 5512493 (1996-04-01), Mathis et al.
patent: 5573909 (1996-11-01), Singer et al.
patent: 5637509 (1997-06-01), Hemmila et al.
patent: 5672478 (1997-09-01), Singh et al.
patent: 5674698 (1997-10-01), Zarling et al.
patent: 5698397 (1997-12-01), Zarling et al.
patent: 5736410 (1998-04-01), Zarling et al.
Beverloo et al., Inorganic Phosphors as New Luminescent Labels for Immunocytochemistry and Time-Resolved Microscopy. Cytometry. vol. 11, pp. 784-792, Oct. 1990.
Allain et al., "Room Temperature CW Tunable Green Upconversion Holmium Fibre Laser," Electronics Letters (1990) 26:261-263.
Allain et al., "Blue Upconversion Fluorozirconate Fibre Laser", Electronic Letters, (1990) 26:166-168.
Auzel, "Materials and Devices Using Double-pumped Phosphors and Energy Transfer", Proceedings of the IEEE (1973) 61:758-786.
Berthou and Jorgensen "Optical-fibre temperature sensor based on upconversion-excited fluorescence", Optic Letters (1990) 15:1100-1102.
Bethune et al., "Atoms in carbon cages: the structure and properties of endohedral fullerences", Nature (1993) 366:123-128.
Beverloo et al., "Preparation and microscopic visualization of multicolor luminescent immunophosphors", Cytometry (1992) 13:561-570.
Beverloo et al., "Inorganic phosphors as new luminescent labels for immunocytochemistry and time-resolved microscopy," Cytometry (1990) 11:784-792.
B.J. Tromberg et al. "Proc. SPIE-INT" Soc. Opt. Eng., (1991) 1427:101-108.
Camus et al., "Two-photon absorption spectroscopy in ytterbium", J. Phys. B: Atom. Molec. Phys. (1978) 11:L395-L397.
Campiglia, A.D. et al., "Utilization of an Inorganic Phosphor as a Reference Signal in Solid-Surface Room Temperature Phosphorimetry", Anal. Chem. (1988) vol. 60(g):2165-2167.
D.C. Yeh et al., "J. Appl. Phys"., (1988) 63:4644-4650.
D.C. Yeh et al., "Phys. Rev. B", (1989) 39:80-90.
Diamandis and Christopoulos, Detection of Lanthanide Chelates and Multiple Labeling Strategies Based on Time-resolved Fluorescence, in Nonisotopic DNA Probe Techniques, Academic Press (1992) 263-274.
D.R. Tallant et al., J. Chem. Phys., (1975) 63:2074-2085.
Eichstein et al., "Laser-excited Time-resolved Solid-phase Fluoroimmunoassays with the New Europium Chelate 4, 7-bis (chlorosulfophenyl)-1, 10-phenanthroline-2, 9-dicarboxylc Acid as Label," Anal. Chem. (1988) 60:1069-1074.
Evangelista et al., "Enzyme-amplified Lanthanide Luminescence for Enzyme Detection in Bioanalytical Assays," Anal.Biol. (1991) 137:213-224.
Gudgin Templeton et al., "Time Resolved Fluorescence Detection of Enzyme-amplified Lanthanide Luminescence for Nucleic Acid Hybridization Assays," Clin. Chem. (1991) 37/9:1509-1512.
Hemmila et al., "Europium as a Label in Time-resolved Immunofluorometric Assays," Anal.Biol. (1984) 137:335-343.
Johnson et al., "Infrared-to-visible Conversion by Rare-earth Ions in Crystals," J. Appl. Phys. (1972) 43:3.
Johnston and Wright, "Trace Analysis of Nonfluorescent Ions by Associate Clustering with a Fluorescent Probe," Anal. Chem. (1979) 51:1774-1780.
Kano et al., NaLnF.sub.4 : YB.sup.3+, Er.sup.3+, (Ln:Y,Gd,La): Efficient Green-emitting Infrared-excited Phosphors, J. Electrochem. Soc. (1972) 119:1561-1564.
Leif and Vallarino, "Rare-earth Chelates as Fluorescent Marks in Cell Separation and Analysis," Cell Separation Science and Technology (1991) 3:41-58.
Lenth and Macfarlane, Lasers, Optics & Photonics News, (1992) 3:8-15.
Louge et al., "Optical Fiber Measurements of Particle Velocity Using Laser-induced Phosphorescence," Applied Optics (1991) 30:1976-1981.
Lovgren et al., "Detection of Lanthanide Chelates by Time-resolved Fluorescence, in Nonisotopic DNA Probe Techniques" Academic Press (1992) 227-261.
Manashirov et al., "Effect of the Purity of Initial Substances on Luminescence Intensity of Erbium in Anti-stroke Luminophores," Chemical Abstracts, (1989) 110:457 Abstract No. 30750B.
McFarlane, "Dual Wavelength Visible Upconversion Laser," Appl. Phys. Letts. (1989) 54:2301-2302.
McFarlane, "Violet Cw Neodymium Upconversion Laser," Appl. Phys. Letts. (1988) 54:1300-1302.
Mukkala et al., "The Synthesis and Use of Activate N-benzyl Derivatives of Diethylenetriaminetetraacetic Acids: Alternative Reagents for Labeling of Antibodies with Metal Ions," Anal. Bio. (1989) 176:319-325.
Nguyen et al., "Blue-green (450-nm) Upconversion Tm.sup.3+ : Ylf Laser," Applied Optics (1989) 28:3553-3555.
P.A. Santa Cruz, et al., "Quim, Nova" (1983) 6:149-151.
Rich and Pinow, Exploring the Ultimate Efficiency in Infrared-to-Visible Coverting Phosphors Activated with Er and Sensitized with Yb, J. Appl. Phys. (1972) 43:2357-2365.
Schindele and Renzoni, "Ultra Fluors: New Fluorophores for Immunological Applications", J. Clin. Immun. (1990) 13:182-186.
Seveus et al., "Time-Resolved Fluorescence Imaging of Europium chelate Label in Immunohistochemistry and in Situ Hybridization," Cytometry (1992) 13:329-338.
Silversmith et al., "Green Infrared-Pumped Erbium Upconversion Laser," J. Opt. Soc. Am. (1982) 3:128-12.
Smart et al., "Cw Room Temperature Upconversion Lasing at Blue, Green and Red Wavelengths in Infrared-Pumped Pr.sup.3 -doped Fluoride Fibre," Electronics Letters (1991) 27:1307-1309.
Soini and Kojola, "Time-resolved Fluorometer for Lanthanide Cachelates--a New Generation of Nonisotopic Immunoassays," Clin Chem. (1983) 29/1:65-68.
Soules and Hoffman, "Luminescent Materials (Phosphors)," Encyclopedia of Chemical Technology, (1981) Third Edition, 14:527-545.
Tiffany, "Fluorometry, Nephelometry, and Turbidimetry," Textbook of Clinical Chemistry, (1986) 78-90.
Voller, "The Enzyme Linked Immunosorbent Assay (ELISA)," in Diagnostic Horizons, (1978) 2:1:1-7.
Xu and Hemmila, "Co-fluorescence Enhancement System Based on Pivaloyltrifluoroacetone and Yttrium for the Simultaneous Detection of Europium, Terbium, Samarium and Dysprosium," Anal. Chimica Acta. (1992) 256:9-16.
Wojciechowski, et al., "Infrared-to-Blue Up-coverting Phosphor," Electron Technology (1978) 11:3:31-47.
Moser, K., et al., "Infrared Spectra
Burton Jarrett Lee
Cooper David E.
Dyer Mark J.
Faris Gregory W.
Kane James
SRI - International
Wilder Cynthia
Zitomer Stephanie W.
LandOfFree
Up-converting reporters for biological and other assays does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Up-converting reporters for biological and other assays, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Up-converting reporters for biological and other assays will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-215335