Unsymmetrical methine and polymethine dye-molecules for...

Details Unsymmetrical methine and polymethine dye-molecules for... Unsymmetrical methine and polymethine dye-molecules for...

2006-04-04

2006-04-04

Northington Davis, Zinna (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S255000, C546S264000, C546S329000, C106S031450, C008S192000

Reexamination Certificate

active

07022858

ABSTRACT:
A new class of alpha-cyanomethine and alpha-cyanopolymethine dyes is provided having moieties which serve for the covalent attachment to biological substrates and resulting in the fluorescent labeling of the substrates. The labeled substrates are useful in analytical techniques for the detection and measurement of biological and clinical compounds of interest. Of particular interest is a class of methine molecules which are non-fluorescent in buffer solutions but intensely fluoresce when they enter a cell.

REFERENCES:
Ca 121:296362, “Factors underlyin the variability of lipid droplet fluroescence in MA-10 Leydig tumor cells”, Gocze et al.
Bradamante et al, Journal of Physical Organic Chemistry, vol. 10, pp. 514-524, 1997.

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