Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-06-30
1986-03-25
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
548187, 514256, 548203, 548204, 514269, 548206, 548213, 514272, 548225, 548226, 514274, 548227, 548228, 514275, 548229, 548235, 514359, 548236, 514362, 514363, 514365, 514369, 514370, 514372, 514374, 514376, 514377, 514378, 514380, 514383, 514384, 544238, 544239, 544298, 544333, 544405, 548127, 548128, 548134, 548135, 548136, 548182, 548183, 548186, A61K 3138, A61K 3141, A61K 31415, A61K 3142, A61K 31425, A61K 31495, A61K 3150, C07D40312, C07D41312, C07D41712
Patent
active
045783888
ABSTRACT:
The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino). N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido) groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
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Durant Graham J.
Ganellin Charon R.
Daus Donald G.
Foggio Richard D.
Keps Joan S.
Lourie Alan D.
SmithKline & French Laboratories Limited
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