Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-02-10
1994-06-14
Yarbrough, Amelia Burgess
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435968, 436800, 546165, 546176, 546270, 546271, C07H 2102, C07H 2104
Patent
active
053211308
ABSTRACT:
The invention relates to unsymmetrical cyanine dyes with a cationic side chain, typically benzothiazole or benzoxazole derivatives, that exhibit enhanced fluorescence on binding with DNA or RNA, where such fluorescence can be used for evaluating the presence of nucleic acid polymers. The dyes generally have the formula: ##STR1## where R.sup.1 is an alkyl group having 1-6 carbons; X is 0, S, or NR.sup.2, where R.sup.2 is an alkyl group having 1-6 carbons, or CR.sup.3 R.sup.4, where R.sup.3 and R.sup.4, which may be the same or different, are alkyl groups having 1-6 carbons;
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Barni et al., Helv. Chim. Acta., 64(6) (1981); pp. 1943-1948.
Brooker, et al., J. Am. Chem. Soc. 64, 199 (1942).
Lee, et al., Thiazole Orange: A New Dye for Reticulocyte Analysis, Cytometry 7, 508-517 (1986).
Griffiths, Colour and Constitution of Organic Molecules, pp. 241 Academic Press (1976).
Rago et al., Analytical Biochemistry 191, 31 (1990).
Houben-Weyl Methoden Der Organischen Chemie, Band V/1d, pp. 231-299 (1972).
Haugland Richard P.
Huang Zhijian
Johnson Iain D.
Yue Stephen T.
Burgess Yarbrough Amelia
Helfenstein Allegra J.
Molecular Probes, Inc.
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