Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones a

Details Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones a Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones a

1988-07-19

1990-01-16

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

546204, 548528, 552255, 514908, C07C 8764, C07D29512

Patent

active

048944513

ABSTRACT:
The disclosure describes unsymmetrical 1,4-bis-(aminoalkylamino)-anthracene-9,10-diones useful in the treatment of neoplasms. Also described is a process of preparing same starting from 1,4-dimethoxyanthracene-9,10-dione which is reacted with an aminoalkylamine. The reaction product is treated with a dialkylaminoethylamine or a N-heteroethylamine to give the unsymmetrical compound.

REFERENCES:
patent: 3446817 (1969-05-01), Harvey et al.
patent: 3576587 (1971-04-01), Kalopissis et al.
patent: 4456552 (1984-06-01), Murdock et al.
Krapcho et al, J. Org. Chem., vol. 49 (12-1984) pp. 5253-5255.

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