Unsaturated cephalosporin derivatives

Details Unsaturated cephalosporin derivatives Unsaturated cephalosporin derivatives

1982-07-19

1984-12-04

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 21, 544 22, 544 26, 544 27, 2602453, C07D50118, A61K 31425

Patent

active

044864264

ABSTRACT:
An antibacterial cephalosporin derivative of the formula I: ##STR1## in which X.sup.1 is sulphur, oxygen, sulphinyl or sulphonyl; R.sup.1 is a variety of radicals defined in the specification; R.sup.2 is any one of the C-4 substituents from antibacterially-active cephalosporins known in the art; R.sup.3 is hydrogen or methoxy; X.sup.2 is nitrogen or a radical N.sup..sym. R.sup.8 ; R.sup.4 and R.sup.8 are a variety of radicals described in the specification; --A-- is of the formula V or VI: ##STR2## in which R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13 and R.sup.14 are a variety of substituents described in the specification; and the pharmaceutically-acceptable acid- and base-addition salts thereof. Pharmaceutical compositions and manufacturing processes are also described.

REFERENCES:
patent: 4283397 (1981-08-01), Hannah

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