Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1991-05-13
1992-07-28
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
560171, 560145, 514113, 558418, 558420, 562 11, A61K 3166
Patent
active
051341344
ABSTRACT:
Unsaturated aminodicarboxylic acid derivatives of formula I ##STR1## wherein A is a divalent aliphatic hydrocarbon radical containing 2 carbon atoms and R.sub.1 and R.sub.2 are each independently of the other free or esterified carboxyl groups, and salts thereof, have a pronounced and selective antagonistic action against N-methyl-D-aspartic acid (NMDA)-sensitive excitatory amino acid receptors. These compounds are prepared, for example, by converting, in a formula of formula II ##STR2## wherein Z.sub.1 and Z.sub.2 are hydroxy or protected hydroxy and Z.sub.3 is protected amino, Z.sub.3 into amino and, if present, converting protected hydroxyl groups Z.sub.1 and/or Z.sub.2 into hydroxy and, if desired, converting a resultant compound into another compound of formula I, resolving a resultant mixture of isomers into the individual components and separating the desired preferred isomer and/or converting a resultant free compound into a salt or a resultant salt into the corresponding free compound.
REFERENCES:
patent: 4399287 (1983-08-01), Baillie et al.
patent: 4469643 (1984-09-01), Tsuruoka et al.
patent: 4477391 (1984-10-01), Collins
patent: 4483853 (1984-11-01), Collins et al.
patent: 4761405 (1988-08-01), Rzeszotarski et al.
patent: 4776875 (1988-10-01), Loher et al.
patent: 4916125 (1990-04-01), Herrling et al.
Br. J. Pharmacol. 99, 791-797 (1990).
Agrar. Biol. Chem. 40, 1905-1906 (1976).
Agrar. Biol. Chem. 41, 573-579 (1977).
Pol. J. Pharmacol. Pharm. 37, 575-584 (1985).
Ciba-Geigy Corporation
Fishman Irving M.
Kaiser Karen G.
Reamer James H.
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