Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-08-06
2000-08-15
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514567, 514561, 514539, 514510, 514357, 514438, 560 36, 546333, 549 77, 562441, A61K 3144, A61K 31195, A61K 3124, A61K 3121, A61K 3138
Patent
active
061037435
ABSTRACT:
Described herein are compounds having the general formula: ##STR1## Ar.sub.1 and Ar.sub.2 are independently selected aryl groups, optionally substituted with substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, alkanoyl, aralkyl, aralkyloxy, halo, NO.sub.2, Ph, CF.sub.3, CN, OH, methylenedioxy, ethylenedioxy, SO.sub.2 NRR', NRR', CO.sub.2 R (where R and R' are independently selected from the group consisting of H and alkyl) and a second aryl group, which may be substituted as above;
wherein any cycloalkyl or aryl substituent is linked to Ar.sub.1 or Ar.sub.2 by a bridging element which may be a single bond, a vinylene group, an ethynylene group, a Z group, a --Z--(CH.sub.2).sub.n -- group, a --(CH.sub.2).sub.n --Z-- group, or a --Z--(CH.sub.2).sub.n --Z-- group, where Z represents an O atom, a S atom, an NH group or an N-alkyl group, and n is an integer from 1 to 4;
wherein Ar.sub.1 and Ar.sub.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group;
R is H, alkyl or the counter ion for a basic addition salt;
R.sub.1 and R.sub.2 are independently selected from the group consisting of H, alkyl and benzyl;
REFERENCES:
Chemical Abstracts, citation 5199 g, vol. 64, Cyclization at carbon-carbon double bond. II. Synthesis of 4-substituted prolines by Pictet-Spengler reaction. p. 5199, 1966.
Bell Stanley Charles
Da Silva Kathleen
Hopper Allen
Isaac Methvin
Meade Eric A.
Allelix Neuroscience Inc.
Davis Zinna Northington
Robinson Zi Binta
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