Universally applicable detection system based on ultra small col

Details Universally applicable detection system based on ultra small col Universally applicable detection system based on ultra small col

1995-10-04

1999-02-16

Chin, Christopher L.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

435 792, 435 793, 435 794, 435 795, 436501, 436512, 436518, 436801, 5303911, 5303913, 530811, 252302, G01N 33553

Patent

active

058720138

ABSTRACT:
An aggregate for qualitatively or quantitatively determining bindable substances. Said aggregate comprises an ultra small colloidal particle and a specific binding agent characterized in that the mean diameter of the colloidal particle is below 2 nm. Preferably the size of the metal particle is selected so that the aggregate is capable of penetrating in standard biological specimens. The invention further provides a universally applicable detection system for determining bindable substances in particular in living material. Further there is provided a process for preparing said aggregate.

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Horisberger, "Colloidal Gold as a tool in molecular biology", TIBS, Nov., 1983 pp. 395-397.
Roth, "The Colloidal Gold Marker System for Light and Electron Microscopic Cytochemistry," in Immunocytochemistry 2, Academic Press, London, (1984), pp. 217-284.

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