Universal supports for oligonucleotide synthesis

Details Universal supports for oligonucleotide synthesis Universal supports for oligonucleotide synthesis

2004-05-24

2009-02-17

Shibuya, Mark L (Department: 1639)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C564S123000, C564S152000, C564S155000, C564S161000, C564S192000, C564S193000, C564S194000

Reexamination Certificate

active

07491817

ABSTRACT:
Universal supports for oligonucleotide synthesis include a support material represented by the following formula:In this formula, substituent A is selected from H, alkyl, aryl, or a polymeric or silica base material; substituent B is selected from acyl, aroyl, or a polymeric or silica base material; and substituent C is selected from a dimethoxytrityl group or a protecting group removable under acidic or neutral conditions. For the supports, one of substituents A or B constitutes the polymeric or silica base material. In use, an oligonucleotide is attached to the support at substituent C.

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