Universal support for the synthesis of oligonucleotides

Details Universal support for the synthesis of oligonucleotides Universal support for the synthesis of oligonucleotides

1998-07-24

2000-07-18

Lukton, David

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

585428, 568700, C07H 2100

Patent

active

06090934&

ABSTRACT:
A universal polymer support containing an organic aliphatic molecule of structure ##STR1## having at least a pair of cis-hydroxyl groups where one of the hydroxyl groups is attached to the polymer support through a covalent linkage and the other hydroxyl group is protected by an acid labile group.

REFERENCES:
Hermanson, Immobilized Affinity Liquid Techniques (Academic Press) pp. 6-10, 1992.
Morrison & Boyd, "Organic Chemistry" pp. 1120-1127, 1973.
Matthew H. Lyttle, et al.: "A New Universal Linker for Solid Phase DNA Synthesis"; Nucleic Acids Research, 1996, vol. 24, No. 14; pp. 2793-2798.
M.E. Schwartz, et al.; "A Universal Adapter for Chemical Synthesis of DNA or RNA on any Single Type of Solid Support"; Tetrahedron Letters, vol. 36, No. 1, 1995; pp. 27-30.

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