Universal solid supports and methods for their use

Details Universal solid supports and methods for their use Universal solid supports and methods for their use

1996-04-22

1999-02-09

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

536 253, 536 2534, 536 254, 546184, 564463, 564499, C07C21104, C07C21105, C07C295027, C07C29503

Patent

active

058696962

ABSTRACT:
Universal solid support oligonucleotide synthesis reagents, oligonucleotide synthesis processes, and reagents for cleaving oligonucleotides from solid supports are disclosed. Oligonucleotide synthesis reagents have the following general formula:

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patent: 4552957 (1985-11-01), McEntire
patent: 5189221 (1993-02-01), Duranleau et al.
"A Universal Glass Support For Oligonucleotide Synthesis," J.S. de Bear, Nucleosides & Nucleotides, 6(5), 821-830 (1987).
"A Universal Adapter for Chemical Synthesis of DNA or RNA on any Single Type of Solid Support," M.E. Schwartz, Tetrahedron Letters, vol. 36, No. 1, pp. 27-30 (1995).
Tetrahedron Report Number 309, "Advances in the Synthesis of Oligonucleotides by the Phosophoramidite Approach," S. Beaucage, Tetrahedron, vol. 48, No. 12, pp. 2223-2311 (1992).
"Synthesis of oligonucleotides on cellulose by a phosphotriester method," R. Crea, Nucleic Acids Research, vol. 8, No. 10 (1980).
Yu, C.J., "A universal support and modified ammonia deprotection for synthesis of oligonucleotides: DNA oligomer synthesis," by BioGenex, San Ramon, CA, AACC Nucleic Acid Conference in San Diego, CA, Abstract No. 51 (1995).

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