Universal linker for combinatorial synthesis

Details Universal linker for combinatorial synthesis Universal linker for combinatorial synthesis

1999-10-20

2000-07-25

Celsa, Bennett

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

436531, 436518, 436523, 530335, 562426, 562431, 562466, 562471, 562472, 564123, 564161, 564162, 564163, 568583, 568626, 568630, 568667, G01N 33543, G01N 33545, C07C 5948, C07C 5956, C07C23100

Patent

active

060937998

ABSTRACT:
A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## wherein t is 0 or 1; n is 3-20; R is OH, an activated ester or the residue of a solid support having a plurality of amino functionalities; A is --O-- or --NH-- and Q is hydrogen or a protecting group for an amine or alcohol.

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