Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1993-07-01
1998-01-06
Ziska, Suzanne E.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
4351723, 536 231, 800DIG1, C12N 1500, C07H 2102
Patent
active
057057320
ABSTRACT:
Genetically engineered cells are provided which can serve as universal donor cells in such applications as reconstruction of vascular linings or the administration of therapeutic agents. The cells include a coding region which provides protection against complement-based lysis, i.e., hyperacute rejection. In addition, the cell's natural genome is changed so that functional proteins encoded by either the class II or both the class I and the class II major histocompatibility complex genes do not appear on the cell's surface. In this way, attack by T-cells is avoided. Optionally, the cells can include a self-destruction mechanism so that they can be removed from the host when no longer needed.
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Bell Leonard
Bothwell Alfred L.M.
Elliot Eileen A.
Flavell Richard A.
Madri Joseph
Oklahoma Medical Research Foundation
Yale University
Ziska Suzanne E.
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