Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1995-06-07
2000-08-08
Campbell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 25, 623 1, 623 11, 424 9321, 435325, 435455, 435465, C12N 1585, A01K 6700, A61K 4800, A61F 206
Patent
active
06100443&
ABSTRACT:
Genetically engineered cells are provided which can serve as universal donor cells in such applications as reconstruction of vascular linings or the administration of therapeutic agents. The cells include a coding region which provides protection against complement-based lysis, i.e., hyperacute rejection. In addition, the cell's natural genome is changed so that functional proteins encoded by either the class II or both the class I and the class II major histocompatibility complex genes do not appear on the cell's surface. In this way, attack by T-cells is avoided. Optionally, the cells can include a self-destruction mechanism so that they can be removed from the host when no longer needed.
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Grusby et al. Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science, vol. 253, pp. 1417-1420, Sep. 20, 1991.
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Bell Leonard
Bothwell Alfred L. M.
Elliot Eileen A.
Flavell Richard A.
Madri Joseph
Campbell Bruce R.
Clark Deborah J. R.
Oklahoma Medical Research Foundation
Yale University
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