Universal carrier for targeting molecules to Gb3 receptor...

Details Universal carrier for targeting molecules to Gb3 receptor... Universal carrier for targeting molecules to Gb3 receptor...

2003-07-29

2009-12-15

Minnifield, Nita M (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S184100, C424S185100, C424S190100, C424S193100, C424S234100, C530S300000, C530S324000, C530S350000

Reexamination Certificate

active

07632514

ABSTRACT:
The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.

REFERENCES:
patent: 4810643 (1989-03-01), Souza
patent: 5994311 (1999-11-01), Eichner et al.
patent: 6613882 (2003-09-01), Goud et al.
patent: 6652857 (2003-11-01), Williams et al.
patent: 6777202 (2004-08-01), Lubitz et al.
patent: 6855321 (2005-02-01), Rappuoli et al.
patent: 7488809 (2009-02-01), Goud et al.
patent: 2004/0047883 (2004-03-01), Goud et al.
patent: 2004/0110935 (2004-06-01), Johannes et al.
patent: 2006/0008475 (2006-01-01), Johannes et al.
patent: 2009/0035330 (2009-02-01), Dewerchin
patent: 2009/0092578 (2009-04-01), Su et al.
patent: 2766193 (1999-01-01), None
patent: 1229045 (2002-08-01), None
patent: 1386927 (2004-02-01), None
patent: WO 95/11998 (1995-05-01), None
patent: WO 99/03881 (1999-01-01), None
patent: WO 02/060937 (2002-08-01), None
patent: WO 2004/016148 (2004-02-01), None
Kim et al, Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy, 2003, 43:294 Abstract.
Ling et al, Biochemistry, 1998, 37:1777-1788.
Su et al, Infection and Immunity, 1992, 60/8:3345-3359.
Sandvig, Toxicon, 2001, 39:1629-1635.
Schoen et al, International J. Medical Microbiology, 2004, 294:319-335.
Xu et al, Vaccine, 2003, 21:644-648.
Tzschaschel et al, Microbial Pathogenesis, 1996, 21:277-288.
Bast t al, Molecular Microbiology, 1999,32/5:953-960.
Dubos et al, J. Exp. Med., 1946, 56:143-156.
O'Loughlin et al, Microbes and Infection, 2001, 3:493-507.
Herold et al, International J. Medical Microbiology, 2004, 294:115-121.
Makino et al, Microbial Pathog nesis, 2001, 31:1-8.
Sandvig et al, FEBS Letters, 2002, 529:49-53.
Ohmura-Hoshino et al, Vaccine, 2004, 22:3751-3761.
Tarrago-Trani et al, Protein Expression and Purification, 2004, 38:170-176.
Hagn r Ile et al, J. Structural Biology, 2002, 139:113-121.
Pruimboom-Brees et al, PNAS,USA, 2000, 97/19:10325-10329.
Rapak et al, PNAS, USA, Apr. 1997, 94:3783-3788.
Mallard et al, JCB, Nov. 16, 1998, 143/4:973-990.
Johann s et al, JBC, Aug. 1, 1997, 272/31:19554-19561.
Ryd et al, Microbial Pathogenesis, 1992, 12:399-407.
Waldrep, Drugs of Today, 1998, 34/6:549-561.
Calderwood et al, PNAS,USA, Jul. 1987, 84:4364-4368.
Sandvig et al, Nature, Aug. 1992, 358:510-512.
Seidah et al, JBC, Oct. 25, 1986, 261/30:13928-13931.
Sandvig et al, JCB, Jul., 1994, 126/1:53-64.
Jones et al, Immunology Letters, Dec. 1990, 26/3:285-290.
Gaidamakova et al, J. Controlled Release, 2001, 74/1-3:341-347.
Ling et al, Structure, 2000, 8:253-264.
Gariepy, Critical Reviews in Oncology/Hematology, 2001, 39:99-106.
Vingert et al, Eur. J. Immunol., 2006, 36:1124-1135.
Su et al, Microbial Pathogenesis, Dec. 1992, 13/6:465-476 absctract only.
Su et al, Infection and Immunity, Aug. 1992, 60/8:3345-3359 abstract only.
Perera et al, J. Bacteriology, Feb. 1991, 173/3:1151-1160.
Tarrago-Trani et al, Photochemistry and Photobiology, 2006, 82:527-537.
Shigematsu et al., Journal of Biotechnology, vol. 75, pp. 23-31 (1999).
Schelte et al., Bioconjugate Chem, vol. 11, pp. 118-123 (2000).
Noakes et al., FEBS Letters, vol. 453, pp. 95-99 (1999).
Haicheur et al., The Journal of Immunology, pp. 3301-3308 (2000).
Lee et al., Eur. J. Immunol., vol. 28, pp. 2726-2737 (1998).
Bao-Yuan Lu et al., Biochemistry, vol. 44 (45), pp. 15032-15041 (2005).
Bartkowski, Richard et al., Journal of Protein Chemistry, vol. 21, No. 3, pp. 137-143 (2002).
Masaharu Ishikawa et al., Cell Structure and Function, vol. 17, pp. 61-65 (1992).

Affiliated with

Also associated with

Rating

Universal carrier for targeting molecules to Gb3 receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Universal carrier for targeting molecules to Gb3 receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Universal carrier for targeting molecules to Gb3 receptor... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4071107