Universal allyl linker for solid-phase nucleic acid synthesis

Details Universal allyl linker for solid-phase nucleic acid synthesis Universal allyl linker for solid-phase nucleic acid synthesis

1997-05-06

1999-12-21

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554213, 560 57, 560 58, 560101, 562468, 562470, 564181, C07C 5900

Patent

active

060051256

ABSTRACT:
A universal linker for solid-phase nucleic acid synthesis that is cleaved under conditions orthogonal to those used during the synthesis and deprotection of nucleic acids such as dsDNA or RNA fragments is disclosed. The invention includes compounds of the formula: ##STR1## wherein R.sub.1 is selected from the group consisting of OH, OR.sub.2 and an amino functionalized support and n is an integer ranging from about 1 to about 1000 or more preferably from about 1 to about 100 or greater and R.sub.2 is an alkyl (C.sub.1-20) or greater.

REFERENCES:
Beaucage et al, Tetrahedron, vol. 48, pp. 2223-2311, 1992.
Pon, Protocols for Oligonucleotides and Analogs,Agrawal,S.ed.;Humana Press:Totowa,NJ, vol. 20, 1993.
Umbreit et al, Journal of American Chemical Society, vol. 99, pp. 5526-5528, 1977.

Affiliated with

Also associated with

Rating

Universal allyl linker for solid-phase nucleic acid synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Universal allyl linker for solid-phase nucleic acid synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Universal allyl linker for solid-phase nucleic acid synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-506737