Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-06-21
2011-06-21
Allen, Marianne P (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S009800, C514S009900, C514S010100, C530S398000
Reexamination Certificate
active
07964562
ABSTRACT:
A novel ovulatory induction paradigm entails administration of hCG in combination with FSH during all stages of treatment, where the ratio of FSH to hCG is adjusted to optimize ovulatory stimulation and minimize complications. The use of compositions characterized by various FSH:hCG ratios enables the practitioner readily to tailor the treatment regimen and accommodate different therapeutic goals as well as individual patient responses to gonadotropin administration.
REFERENCES:
patent: 5656597 (1997-08-01), Skrabanja et al.
patent: 5929028 (1999-07-01), Skrabanja et al.
patent: 2003/0181361 (2003-09-01), Sharma et al.
patent: 2004/0142887 (2004-07-01), Cui et al.
patent: 2004/0248784 (2004-12-01), Filicori
patent: 2006/0135421 (2006-06-01), Filicori
patent: 2006/0229288 (2006-10-01), Palmer et al.
patent: 2008/0119394 (2008-05-01), Filicori
patent: 1 364 658 (2003-11-01), None
patent: WO 00/67778 (2000-11-01), None
patent: WO-00/67778 (2000-11-01), None
patent: WO-03/022302 (2003-03-01), None
patent: WO-03/022303 (2003-03-01), None
Filicori et al. Low-dose human chorionic gonadotropin therapy can improve sensitivity to exogenous follicle-stimulating hormone in patients with secondary amenorrhea. Fertility and Sterility. vol. 72, No. 6, (Dec. 1999).
Filicori et al., “Stimulation and Growth of antral ovarian fillicles by selective LH activity administration in women,”Journal of Clinical Endrocrinology and Metabolism, Mar. 2002, pp. 1156-1161.
Filicori et al., “Luteinizing hormone activity supplementation enhances follicle-stimulating hormone efficacy and improves ovulation induction outcome,”Journal of Clinical Endocrinology and Metabolism, vol. 84, No. 8, Aug. 1999, pp. 2659-2663.
Thompson et al., “Gonadotrophin requirements of the developing follicle,”Fertility and Sterility, vol. 63, No. 2, Feb. 1995, pp. 273-276.
Ascoli, “Characterization of Several Clonal Lines of Cultured Leydig Tumor Cells: Gonadotropin Receptors and Steroidogenic Responses,” Endocrinology, 1981, pp. 88-95, vol. 108, No. 1, The Endocrine Society.
Campbell et al., “Examination of the Relative Role of FSH and LH in the Mechanism of Ovulatory Follicle Selection in Sheep,” Journal of Reproductive and Fertility, 1999, pp. 355-367, vol. 117, Journals of Reproduction and Fertility Ltd.
Chang et al., “Recombinant Human Chorionic Gonadotropin (rhCG) in Assisted Reproductive Technology: Results of a Clinical Trial Comparing Two Doses of rhCG (OvidrelR) to Urinary hCG (ProfasiR) for Induction of Final Follicular Maturation in in vitro Fertilization-Embryo Transfer,” Fertility and Sterility, Jul. 2001, pp. 67 74, vol. 76, No. 1, American Society for Reproductive Medicine.
Chappel et al., “Biosynthesis and Secretion of Follicle-Stimulating Hormone,” Endocrine Reviews, 1983, pp. 179-211, vol. 4, No. 2, The Endocrine Society.
Clasesson L., et al., “Crystalline Human Chorionic Gonadotrophin and its Biological Action,” ACTA Endocrinologica, 1948, vol. I, pp. 1-18.
Dighe et al., “Use of a- and /3-Subunit Specific Antibodies in Studying Interaction of hCG with Leydig Cell Receptors”, Archives of Biochemistry and Biophysics, Sep. 1983, pp. 490-499, vol. 225, No. 2, Academic Press, Inc.
Fevold, H. L. et al., “Studies in the Physical Chemistry of the Anterior Pituitary Hormones,” Endocrinology, May 1940, vol. 26, pp. 999-1004.
Filicori et al., “Modulation of Folliculogenesis and Steroidogenesis in Women by Graded Menotrophin Administration,” Human Reproduction, 2002, pp. 2009-2015, vol. 17, No. 8, European Society of Human J Reproduction and Embryology.
Filicori et al., “The Use of LH Activity to Drive Folliculogenesis: Exploring Uncharted Territories in Ovulation Induction,” Human Reproduction Update, 2002, pp. 543-557, vol. 8, No. 6, European Society of Human Reproduction and Embryology.
Filicori, “Use of Luteinizing Hormone in the Treatment of Infertility: Time for Reassessment?,” Fertility and Sterility, Feb. 2003, pp. 253-255, vol. 79, No. 2, American Society for Reproductive Medicine.
Fraenkel-Conrat et al., “Purification of Follicle-Stimulating Hormone (FSH) of the Anterior Pituitary,” Proc. Soc. Exp. Biol. Med., 1940, vol. 45, pp. 627-630.
Gordon et al., Abstracts of the 13thAnnual Meeting of the ESHRE, 1997, pp. 52-54, Edinburgh.
Greep, B. F., et al., “Separation in Nearly Pure Form of Luteinizing (interstitial Cell-Stimulating) and Follicle-Stimulating (Gametogenic) Hormones of the Pituitary Gland,” J. Biol. Chem., 1940, vol. 133, pp. 289-291.
Gupta et al., “Hyperexpression of Biologically Active Human Chorionic Gonadotropin Using the Methylotropic Yeast,” Pichia Pinions, Journal of Molecular Endocrinology, 1999, pp. 273-283, vol. 22, Society of Endocrinology.
Hillier et al., ‘Follicular Oestrogen Synthesis: The Two-Cell, Two-Gonadotrophin’ Model Revisited, Molecular and Cellular Endocrinology, 1994, pp. 51-54, vol. 100, Elsevier Science Ireland Ltd.
Katzman, P.A., et al., “The Preparation of Chorionic Gonadotropin by Chromatographic Adsorption,” J. Biol. Chem., 1943, vol. 148, pp. 501-507.
Keene et al., “Expression of Biologically Active Human Follitropin in Chinese Hamster Ovary Cells,” The Journal of Biological Chemistry, Mar. 25, 1989, pp. 4769-4775, vol. 264, No. 9, The American Society for Biochemistry and Molecular Biology, Inc.
Li, et al., “Isolation of Pituitary Follicle Stimulating Hormone (FSH),” Science, 1949, vol. 109, pp. 445-446.
Martin et al., “ART: Ovarian Stimulation,” Fertility & Sterility, Oct. 14, 2002, p. S19.
McShan, W.H., et al., “The Preparation and Properties of Pituitary Follicle-Stimulating Fractions Made by Trypsin Disgestion,” J. Biol. Chem., 1940, vol. 135, pp. 473-482.
Remington's Pharmaceutical Sciences, 15thEd. (Mark Publishing Co. 1975), pp. 1405-1412 and 1461-1487.
Shoham, “The Clinical Therapeutic Window for Luteinizing Hormone in Controlled Ovarian Stimulation,” Fertility and Sterility, Jun. 2002, pp. 1170-1177, vol. 77, No. 6, American Society for Reproductive Medicine.
Snyder et al., “Characterization of Human LH Isohormones From Fresh Pituitary Tissue,” Molecular and Cellular Endocrinology, 1987, pp. 115-121, vol. 54, Elsevier Scientific Publishers Ireland Ltd.
Van Hell, H., et at., “Effects of Human Menopausal Gonadotrophin Preparations in Different Bioassay Methods,” ACTA Endocrinologica, 1964, vol. 47, No. 3, pp. 407-418.
Warne et al., “Induction of Ovulation in World Health Organization Group II Anovulatory Women Undergoing Follicular Stimulation with Recombinant Human Follicle-Stimulating Hormone: A Comparison of Recombinant Human Chorionic Gonadotropin (rhCG) and Urinary hCG,” Fertility and Sterility, Jun. 2001, pp. 1111-1118, vol. 75, No. 6, American Society for Reproductive Medicine.
Zondek and Aschheim, Klin, Wochenschr, 1928, vol. 7, pp. 931-932.
Abstracts of the 13thAnnual Meeting of the ESHRE, 1997, pp. 52-54, Edinburgh.
“Induction of ovulation in World Health Organization group II anovulatory women undergoing follicular stimulation with recombinant human follicle-stimulating hormone: a comparison of recombinant human chorionic gonadotropin (rhCG) and urinary hCG”, Fertility and Sterility, Jun. 2001, pp. 1111-1118, vol. 75, No. 6, American Society for Reproductive Medicine.
Bremner, et al., “Follicle-stimulating Hormone and Human Spermatogenesis,” The Journal of Clinical Investigation, vol. 68, Oct. 1981, pp. 1044-1052.
Chow, B. F., et al., “Separation in Nearly Pure Form of Luteinizing (interstitial Cell-Stimulating) and Follicle-Stimulating (Gametogenic) Hormones of the Pituitary Gland”, J. Biol. Chem., vol. 133, pp. 289-291 (1940).
Filicori et al., “Stimulation and Growth of Antral Ovarian Follicles by Selective LH Activity Administration in Women&#x
Allen Marianne P
DeBerry Regina M
Ferring B.V.
Foley & Lardner LLP
LandOfFree
Unitary combinations of FSH and hCG does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Unitary combinations of FSH and hCG, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Unitary combinations of FSH and hCG will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2656080