Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-08-28
1988-03-01
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31415
Patent
active
047286644
ABSTRACT:
There is disclosed a substituted nitroimidazole compound, 1-methyl-2-methylsulfonyl-4-nitroimidazole which is an antiprotozoal and bactericidal compound with the unique and surprising property of being totally non-mutagenic and thus of a much higher degree of safety than is found with other nitroimidazoles. Compositions and methods for the antiprotozoal and bactericidal uses of such compounds are also disclosed.
REFERENCES:
patent: 3644392 (1972-02-01), Henry
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Miwa et al., (I) pp. 527-535, Biological Reactive Intermediates III, Kocsis et al. (Ed.) Plenum Publishing Corp., 1986.
Robbie et al., Am. Obstet. Gynecol., 145: 865-879 (1983).
Goldman, The John Hopkins Medical Journal 147: 1-9 (1980).
Miwa et al., (II) Chem. Biol. Ineractions 50: 189-202 (1984).
Animal Diseases USDA Yearbook of Agriculture 1956, p. 462.
Merck Veterinary Manual, Fifth Ed., p. 1062 (1979).
Bagan Edward S.
Miwa Gerald T.
Kilcoyne John M.
Merck & Co. , Inc.
Meyers Albert T.
Rose David L.
Sudol, Jr. Michael C.
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