Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-10-30
2000-07-25
Park, Hankyel
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4242291, 4242301, 536 2372, 435325, 4353722, 4352351, G01N 3353, C12N 500, A61K 39245, C07H 2104
Patent
active
060935502
ABSTRACT:
This invention provides an isolated DNA molecule which is at least 30 nucleotides in length and which uniquely defines a herpesvirus associated with Kaposi's sarcoma. This invention provides an isolated herpesvirus associated with Kaposi's sarcoma. This invention provides an isolated peptide encoded by the isolated DNA molecule. Further, this invention provides an isolated DNA virus wherein the viral DNA is about 270 kb in size; wherein the DNA encodes a thymidine kinase; and wherein the viral DNA is capable of selectively hybridizing to a nucleic acid probe selected from the group consisting of SEQ. ID NOs: 10-12. This invention provides an antibody specific to the peptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a transgenic nonhuman mammal and a cell line containing at least a portion of the isolated DNA molecule. This invention provides a method of vaccinating a subject for KS, prophylaxis diagnosing or treating a subject with KS and detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.
REFERENCES:
Ioachim et al., Cytomegalovirus, Angiomatosis, and Kaposi's Sarcome: New Observations of a Debated Relationship, Modern Pathology, vol. 5, No. 2, 169-178, see Abstract and pp. 170 and 173, 1992.
Chang Yuan
Moore Patrick S.
Park Hankyel
The Trustees of Columbia University in the City of New York
White John P.
LandOfFree
Unique associated Kaposi's sarcoma virus sequences and uses ther does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Unique associated Kaposi's sarcoma virus sequences and uses ther, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Unique associated Kaposi's sarcoma virus sequences and uses ther will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1335479