Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1995-04-11
1998-09-01
Elliott, George C.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4353201, 435325, 536 2372, 536 2432, C12N 121, C12N 510, C12N 1538, C12N 1563
Patent
active
058010424
ABSTRACT:
This invention provides an isolated DNA molecule which is at least 30 nucleotides in length and which uniquely defines a herpesvirus associated with Kaposi's sarcoma. This invention provides an isolated herpesvirus associated with Kaposi's sarcoma. This invention provides an antibody specific to the peptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a method of vaccinating a subject for KS, prophylaxis, diagnosing or treating a subject with KS and detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.
REFERENCES:
Chang et al. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma, Science 265, 1865-1869 (Exhibit 2) .
Delli Bovi et al. (1987) Isolation of a rearranged human transforming gene following transfection of Kaposi sarcoma, Proc. Natl. Acad. Sci. U.S.A. 84, 5660-5664 (Exhibit 3).
Gallo (1994) New approaches for interfering with human immunodeficiency virus replication and for Kaposi's sarcoma, J. Cellular Biochem. 18B, 108 (Exhibit 4).
Gallo (1993) Aspects of the molecular pathogensis of AIDS, J. Cellular Biochem. 17E, 5 (Exhibit5).
Mosca et al. (1987) Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus, Nature 325, 67-70 (Exhibit 6).
Cesarman et al. (1995) Kaposi's Sarcoma-associated herpesvirus-like DNA sequences are present in AIDS-related body cavity based lymphomas, The FASEB Journal 9, A973, abstract 5650 (Exhibit 7).
Baer et al. (1984) DNA sequence and expression of the B95-8 Epstein-Barr virus genome, Nature 310, 207-211 (Exhibit 8).
Gompels et al. (1988) Conservation of glycoprotein H (gH) in herpesviruses: Nucleotide sequence of the gH gene from herpesvirus saimiri, J. Gen. Virol. 69, 2819-2829 (Exhibit 2).
Gompels et al. (1991) Characterization and sequence analyses of antibody-selected antigenic variants of herpes simplex virus show a conformationally complex epitope on glycoprotein H, J. Virol. 65, 2393-2401 (Exhibit 3).
Forrester et al. (1992) Construction and properties of a mutant of a herpes simplex virus type 1 with glycoprotein H coding sequences deleted, J. Virol. 66, 341-348 (Exhibit 4).
Roop et al. (1993) A mutant herpes simplex virus type 1 unable ot express glycoprotein L cannot enter cells, and its particles lack glycoprotein H, J. Virol. 67, 2285-2297 (Exhibit 5).
Scott et al. (1993) Identification and sequence analysis of the homologues of the herpes simplex virus type 1 glycoprotein H in Marek's disease virus and the herpesvirus of turkeys, J. Gen. Virol. 74, 1185-1190, (Exhibit 7).
Liu et al. (1993) Human herpesvirus-6 glycoprotein H and L homologs are components of the gp100 complex and the gH external domain is the terget for neutralizing monoclonal antibodies, Virology 197, 12-22 (Exhibit 8).
Tewari et al. (1994) Characterization of immune responses to baculovirus-expressed equine herpesvirus type 1 glycoprotein D and H in a murine model, J. Gen. Virol. 75, 1735-1741 (Exhibit 9).
McGowan et al. (1994) Expression and characterization of equine herpesvirus 1 glycoprotein H using recombinant baculovirus, Arch. Virol. 137, 389-395 (Exhibit 10).
Pulford et al. (1994) Expression of the Epstein-Barr virus envelope fusion glycoprotein gp85 gene by a recombinant baculovirus, J. Gen. Virol. 75. 3241-3248 (Exhibit 11).
Farrell et al. (1994) Vaccine potential of a herpes simplex virus type 1 mutant with an essential glycoprotein deleted, J. Virol. 68, 927-932 (Exhibit 12).
Baranowski et al. (1995) Synthesis and processing of bovine herpesvirus-1 glycoprotein H, Virology 206, 651-654 (Exhibit 13).
Giraldo et al (1972) Herpes-type virus particles in tissue culture of Kaposi's sarcoma from different geographic regions, Journal of the National Cancer Institute 49, 1509-1513.
Giraldo et al (1984) Kaposi's sarcoma: a natural model of interrelationships between viruses, immunologic responses, genetics and oncogenesis, Antibiotics and Chemotherapeutics 32, 1-11.
Iochim et al (1992) Cytomegalovirus, angiomatosis, and Kaposi's sarcoma: new observations of a debated relationship, Modern Pathology 5, 169-178.
Jahan et al (1989) Analysis of human KS biopsies and cloned cell lines for cytomegalovirus, HIV-1, and other selected DNA virus sequences, AIDS Research and Human Retroviruses 5, 225-231.
Walter et al (1984) Kaposi's sarcoma: presence of herpes-type virus particles in a tumor specimen, Human Pathology 15, 1145-1146.
Dupin et al (Mar. 25, 1995) Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma, The Lancet 345, 761-762 (Exhibit 2).
Huang et al (Mar. 25, 1995) Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma, The Lancet 345, 759-761 (Exhibit 3).
Su et al (Mar. 18, 1995) Herpesvirus-like DNA sequence in Kaposi's sarcoma from AIDS and non-AIDS patients in Taiwan, The Lancet 345, 722-723 (Exhibit 4).
Chang (Feb. 24, 1995) Letter to the editor, Science 267, 1079 (Exhibit 5).
Cohen (Dec. 16, 1994) Is a new virus the cause of KS?, Science 266, 1803-1804 (Exhibit 6).
Karp and Broder (Apr. 4, 1995) Molecular foundations of cancer: new targets for intervention, Nat Med 1, 309-320 (Exhibit 7).
McGrath et al (Apr. 1, 1995) Identification of a clonal form of HIV in early Kaposi's sarcoma: evidence for a novel model of oncogenesis, "sequential neoplasia" J Acq Immun Def Hum Retrovirol 8, 379-385 (Exhibit 8).
Relman (Feb. 16, 1995) Has trench fever returned?, New Eng J Med 332, 463-464 (Exhibit 9).
Rubin (Jan. 13, 1995) Letter to the editor, Science 267, 157-158 (Exhibit 10).
Schulz and Weiss (Jan. 5, 1995) A finger on the culprit, Nature 373, 17-18 (Exhibit 11).
Chang Yuan
Moore Patrick S.
Elliott George C.
Schwartzman Robert
The Trustees of Columbia University in the City of New York
White John P.
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