Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1984-11-20
1990-05-01
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
260403, 264 41, 264 46, 424 11, 424 71, 4284022, 436829, A61K 966, A61K 3722, B01J 1302
Patent
active
049217062
ABSTRACT:
This invention relates to unilamellar lipid vesicles comprised of short-chain phospholipids and long-chain phospholipids and a method for making the vesicles. The short-chain phospholipids are comprised of fatty acids with fewer than 9 carbons atoms and the long-chain phospholipids are comprised of fatty acids with at least 12 carbon atoms.
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Hauser, H. and N. Gains, Spontaneous Vesiculation of Phospholipids: A Simple and Quick Method of Forming Unilamellar Vesicles, Proceedings of the National Academy of Science USA, 79:1683-1687 (Mar. 1982).
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Roseman, M. A. et al., Properties of Sonicated Vesicles of Three Synthetic Phospholipids, Chemistry and Physics of Lipids, 211:205-222 (1978).
Gabriel Nancy E.
Roberts Mary P.
Lovering Richard D.
Massachusetts Institute of Technology
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