Undenatured virus-free biologically active protein derivatives

Details Undenatured virus-free biologically active protein derivatives Undenatured virus-free biologically active protein derivatives

1983-07-14

1985-09-10

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Lymphokine

260112B, 260112R, 260121, 2601125R, 424101, 514 2, 514 6, A61K 3900, A61K 3514, A61K 3700, C07G 700, C07C10352

Patent

active

045405735

ABSTRACT:
A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein being at least 80% is disclosed. The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and detergent, usually followed by removal of the di- or trialkylphosphate.

REFERENCES:
patent: 3962421 (1976-06-01), Neurath
patent: 4314997 (1982-02-01), Shanbrom
patent: 4315919 (1982-02-01), Shanbrom
Kirk-Othmer, Encyclopedia of Chemical Technology, vol. 4, 3rd Ed., Interscience Pub., 1978, pp. 25-61.
Ser. No. 368,250, Alfred Mayer Prince, filed 4-14-82.

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