Undenatured virus-free biologically active protein derivatives

Details Undenatured virus-free biologically active protein derivatives Undenatured virus-free biologically active protein derivatives

1984-07-17

1988-08-16

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Lymphokine

424101, A61K 3918, A61K 3929

Patent

active

047643692

ABSTRACT:
A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein being at least 80% is disclosed. The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and detergent, usually followed by removal of the di- or trialkylphosphate.

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