Uncoupling protein 5 (UCP5)

Details Uncoupling protein 5 (UCP5) Uncoupling protein 5 (UCP5)

2005-11-18

2008-03-11

Weber, Jon (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S069100, C435S320100, C435S252300, C435S325000, C435S455000, C536S023100, C536S023500

Reexamination Certificate

active

07342102

ABSTRACT:
The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins (“UCPs”) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.

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Vidal-Puig et al. Uncoupling protein UCP3, mitochondrial, human,, SEQ ID No. 7, alignment result 4, Database: PIR—80, Accession No. JC5522.
Vidal-Puig et al. Uncoupling protein UCP3, mitochondrial, human,, SEQ ID No. 9, alignment result 4, Database: PIR—80, Accession No. JC5522.
Vidal-Puig et al. Uncoupling protein UCP3, mitochondrial, human,, SEQ ID No. 11, alignment result 3, Database: PIR—80, Accession No. JC5522.
Vidal-Puig et al. Uncoupling protein UCP3, mitochondrial, human,, SEQ ID No. 13, alignment result 3, Database: PIR—80, Accession No. JC5522.
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EMBL Database: EMHUM1:AF078544 (Accession No. AF078544) 1998.
EMBL Database: EMROD:AB011068 (Accession No. AB011068) 1998.
Fleury et al., “Uncoupling Protein-2: a Novel Gene Linked to Obesity and Hyperinsulinemia,” Nature Genetics. 1997, 15(3): 269-272.
Gibson et al., “A Novel Method for Real Time Quantitative RT-PCR,” Genome Research, 1996, 6(10): 995-1001.
Gimeno et al., Cloning and Characterization of an Uncoupling Protein Homolog; A Potential Molecular Mediator of Human Thermogenesis, Diabetes, 1997, 46(5): 900-906.
Gong et al., “Uncoupling Protein-3 is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and Leptin.” J of Bio. Chem. 1997, 272(39): 24129-24132.
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NCBI/GenBank EST; Locus AA015735 (computer printout).
NCBI/GenBank EST; Locus AA015832 (computer printout).
NCBI/GenBank EST; Locus AA021118 (computer printout).
NCBI/GenBank EST; Locus AA021119 (computer printout).
NCBI/GenBank EST; Locus AA054608 (computer printout).
NCBI/GenBank EST; Locus AA056945 (computer printout).
NCBI/GenBank EST; Locus AA057005 (computer printout).
NCBI/GenBank EST; Locus AA142931 (computer printout).
NCBI/GenBank EST; Locus AA401224 (computer printout).
NCBI/GenBank EST; Locus AA404241 (computer printout).
NCBI/GenBank EST; Locus AA910774 (computer printout).
NCBI/GenBank EST; Locus AI032869 (computer printout).
NCBI/GenBank EST; Locus AI039086 (computer printout).
NCBI/GenBank EST; Locus AI128486 (computer printout).
NCBI/GenBank EST; Locus AI131262 (computer printout).
NCBI/GenBank EST; Locus A1241428 (computer printout).
NCBI/GenBank EST; Locus N48177 (computer printout).
NCBI/GenBank EST; Locus N53324 (computer printout).
NCBI/GenBank EST; Locus R19440 (computer printout).
NCBI/GenBank EST; Locus R44688 (computer printout).
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