Uncoated tablets and method of producing the same

Details Uncoated tablets and method of producing the same Uncoated tablets and method of producing the same

1994-01-28

1995-10-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424489, 424490, A61K 920

Patent

active

054569206

ABSTRACT:
A compression-moldable composition comprising an active ingredient, an excipient and an oily or fatty substance having a lower melting point of about 20.degree. to 90.degree. C. is compression-molded into uncoated tablets without coating to improve the abrasion resistance. The oily or fatty substance includes a higher fatty acid or a salt thereof, a wax, a fatty acid ester, a hardened oil, a polyalkylene oxide, etc., and the amount thereof is about 0.01 to 10% by weight. The composition may comprise (1) a granulated powder containing the active ingredient and the excipient, and the powdery or granular oily or fatty substance having a lower melting point, or (2) a granulated powder containing the active ingredient, the excipient and said oily or fatty substance. Compression-molding of the composition improves the abrasion resistance of the tablet and significantly inhibits the development of powder by wearing or abrasion even when the oily or fatty substance is used in a small amount of about 0.1 to 0.5% by weight.

REFERENCES:
patent: 5055304 (1991-10-01), Makino et al.

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