Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1994-02-25
1995-11-28
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544122, 544264, 544335, 549 28, 549473, C07D41304, C07D41312, C07D47326
Patent
active
054709741
ABSTRACT:
A composition of polymer molecules effective to bind, with substantially uniform binding affinity, to a single-stranded polynucleotide containing a target sequence of bases. The polymer molecules are composed of a sequence of base-pairing moieties effective to hydrogen bond to corresponding, complementary bases in the target sequence, under selected binding conditions, and a predominantly uncharged, achiral backbone supporting the base-pairing moieties at positions and in orientations which allow hydrogen bonding between the pairing moieties of the polymer and the corresponding complementary bases in the target sequence. The composition has diagnostic uses, in a solid-support assay system, and therapeutic uses involving inhibition or inactivation of target polynucleotides.
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Stirchak Eugene
Summerton James
Weller Dwight
Dehlinger Peter J.
Fabian Gary R.
Lee Mary C.
McKane Joseph K.
Neu-Gene Development Group
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