Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1991-11-21
1993-02-09
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
544 82, 528398, 528399, 528403, 528405, 528406, C07D41312, C07D41314, C08G 7902, C08G 7904
Patent
active
051854449
ABSTRACT:
A polymer composition is disclosed composed of morpholino subunit structures linked together by uncharged, chiral linkages, one-three atoms in length. These chiral linkages join the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
REFERENCES:
patent: 4558047 (1985-12-01), Takaya et al.
patent: 5034506 (1991-07-01), Summerton et al.
Stirchak et al., Nucleic Acids Research, vol. 17, No. 15, (1989), pp. 6129-6141.
Khym, J. X., Biochemistry 2 (2):344 (1963).
Mungall, W. S. et al., J. Org. Chem. 42 (4): 703 (1977).
Tittensor, J. R., J. Chem. Soc. (C): 2656 (1971).
Gait, M. J., et al., J. C. S. Perkins I: 1684 (1974).
Jones, A. S., et al., Biochem. et Biphys. Acta 365:365 (1973).
Blake et al., Biochem, 24:6132 (1985a).
Blake et al., Biochem, 24:6139 (1985b).
Froehler, et al., Nucleic Acids Res. 16:4831 (1988).
Jayaraman, et al., Proc Natl. Acad Sci USA 78:1537 (1981).
Miller, et al., Biochemistry 18:5134 (1979).
Miller, et al., J Biol Chem Chem 255:9659 (1980).
Miller, et al., Biochimie 67:769 (1985).
Murakami, et al., Biochemistry 24:4041 (1985).
Pitha, Biochem Biphys Acta 204:39 (1970a).
Pitha, Bipolymers 9:965 (1970b).
Smith, et al., Proc Natl. Acad Sci USA 83:2787 (1986).
Stirchak, E. P. et al., J. Organic Chem. 52:4202 (1987).
Summerton James E.
Weller Dwight D.
Anti-Gene Deveopment Group
Datlow Philip I.
Dehlinger Peter J.
Fabian Gary R.
Shah Mukund J.
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