Uncharged morpholino-based polymers having achiral intersubunit

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From sulfur-containing reactant

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

528403, 528405, 528406, C08G 7518, C08G 7520, C08G 7524

Patent

active

050345060

ABSTRACT:
A polymer composition is disclosed composed of morpholino subunit structures which are linked together by uncharged, achiral linkages. These linkages are one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.

REFERENCES:
CA 112 (13): 119320a Stirchak, E. P. "Uncharged Stereo Regular Nucleic Acid Analogs," Nucleic Acids Res., vol. 17, No. 15, 1989.
CA 110 (22): 202954q Terada, Kazutoshi et al. "Photosensitive Compositions for Printing Plates".
CA 75 (7): 48222z Belikov, V. et al., "Effect of the Polarity of Substituents on the Decomposition Rate of Beta.-Nitroamines," Inst. Elementoorg. Soedin, 1971.
Khym, J. X., Biochemistry 2 (2):334 (1963).
Mungall, W. S. et al., J. Org. Chem. 42 (4):703 (1977).
Tittensor, J. R., J. Chem. Soc. (C):2656 (1971).
Gait, M. J. et al., J. C. S. Perkins I:1684 (1974).
Jones, A. S. et al., Biochem. et Biphys. Acta 365:365 (1973).
Blake et al., Biochem. 24:6132 (1985a).
Blake et al., Biochem. 24:6139 (1985b).
Froehler et al., Nucleic Acids Res. 16:4831 (1988).
Jayaraman et al., Proc Natl Acad Sci U.S.A. 78:1537 (1981).
Miller et al., Biochemistry 18:5134 (1979).
Miller et al., J. Biol. Chem. 255:6959 (1980).
Miller et al., Biochimie 67:769 (1985).
Murakami et al., Biochemistry 24:4041 (1985).
Pitha, Biochem Biphys Acta 204:39 (1970a).
Pitha, Biopolymers 9:965 (1970b).
Smith et al., Proc. Natl. Acad. Sci. U.S.A. 83:2787 (1986).
Stirchak, E. P. et al., Organic Chem. 52:4202 (1987).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Uncharged morpholino-based polymers having achiral intersubunit does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Uncharged morpholino-based polymers having achiral intersubunit , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Uncharged morpholino-based polymers having achiral intersubunit will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-433339

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.