Unagglomerated core/shell nanocomposite particles

Details Unagglomerated core/shell nanocomposite particles Unagglomerated core/shell nanocomposite particles

2005-06-01

2011-12-06

Tran, Susan (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S450000, C435S006120, C436S525000, C436S527000, C428S402000, C428S402200, C428S402240, C428S403000, C428S405000

Reexamination Certificate

active

08071132

ABSTRACT:
The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that contains nanocomposite particles, treating the microemulsion with a silane coupling agent, breaking the microemulsion to form a suspension of the nanocomposite particles by adding an acid/alcohol solution to the microemulsion that maintains the suspension of nanocomposite particles at a pH of between about 6 and 7, and simultaneously washing and dispersing the suspension of nanocomposite particles, preferably with a size exclusion HPLC system modified to ensure unagglomeration of the nanocomposite particles. The primary particle size of the nanocomposite particles can range in diameter from between about 1 to 100 nm, preferably from between about 10 to 50 nm, more preferably about 10 to 20 nm, and most preferably about 20 nm.

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