Ultrasound enhancement of transdermal drug delivery

Details Ultrasound enhancement of transdermal drug delivery Ultrasound enhancement of transdermal drug delivery

1986-07-08

1988-08-30

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

With means for cutting, scarifying, or vibrating tissue

604 20, 604 49, 604 66, 604290, A61B 1720

Patent

active

047674024

ABSTRACT:
The present invention is a method using ultrasound to enhance permeation of molecules through the skin and into the blood stream, at a controlled rate. Depending on the drug being infused through the skin, the rate of permeation is increased as well as the efficiency of transfer. Drugs which may not be effective under other conditions, for example, due to degradation within the gastrointestinal tract, can be effectively conveyed transdermally into the circulatory system by means of ultrasound.

REFERENCES:
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patent: 4280494 (1981-07-01), Cosgrove, Jr. et al.
patent: 4309989 (1982-01-01), Fahim
patent: 4372296 (1983-02-01), Fahim
patent: 4563184 (1986-01-01), Korol
D. M. Skauen and G. M. Zentner, "Phonophoresis", Int. J. Pharm. 20, 235-245, (1984).

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