Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2011-07-19
2011-07-19
Hartley, Michael G (Department: 1618)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C424S078030, C424S401000, C424S486000, C514S002600, C514S04400A
Reexamination Certificate
active
07981442
ABSTRACT:
A method of targeted drug delivery and imaging using nonionic surfactant vesicles (niosomes) in combination with ultrasound. Niosomes have potential applications in targeted drug delivery and imaging because of their ability to encapsulate therapeutic agents and their enhanced uptake by physiological membranes. Ultrasound may be used to mediate delivery non-invasively by altering the niosome membrane structure. Niosomes composed of polyoxyethylene sorbitan monostearate (Tween 61), cholesterol, and dicetyl phosphate were synthesized via a thin film hydration technique and used for encapsulation studies. Carboxyfluorescein dye (CF) was used as a drug model to demonstrate delivery. The amount of dye in the niosomes, the concentration of the vesicles, and their mean particle size after each 5 minute incremental exposure to ultrasound was monitored. Dye concentration in niosome samples decreased while the population and size distribution of the niosome remained largely unchanged. Ultrasound is demonstrated to enhance the rate of dye diffusion across the niosome membrane non-destructively.
REFERENCES:
patent: 4780212 (1988-10-01), Kost et al.
patent: 5580575 (1996-12-01), Unger et al.
patent: 6403056 (2002-06-01), Unger
patent: 6623430 (2003-09-01), Slayton et al.
patent: 6884407 (2005-04-01), Unger
patent: 7169382 (2007-01-01), Chopart et al.
patent: 2003/0064097 (2003-04-01), Patel et al.
patent: 2003/0157025 (2003-08-01), Unger et al.
patent: 2005/0019266 (2005-01-01), Unger
Elizabeth Hood, Monica Gonzalez, Joel strom and Michael VanAuker, Ultrasound Enhancement of Drug Release Across Non Ionic Surfactant Vesicle Membranes, Procedings of the 26th Annual International Conference of the IEEE EMBS San Francisco, CA, USA Sep. 1-5, 2004.
Ijeoma F. Uchegbu and Suresh P. Vyas, Non-ionic surfactant based vesicles (niosomes) in drug delivery, International Journal of Pharmaceutics, 172, 33-70, 1998.
Ka-Yun Ng, Yang Liu, Therapeutic Ultrasound: Its Application in Drug Delivery, Medicinal Research Reviews, vol(2), 204-223, 2002.
Hamilton AJ, Huang SL, Warnick D, Rabbat M, Kane B, Nagaraj A, Klegerman M, McPherson DD. Intravascular ultrasound imaging of atheroma components in vivo. J Am Coll Cardiol 2004:43:453-60.
Tiuknihoy SD, Khan AA, Huang S, Klegerman ME MacDonald RC, McPherson DD. Novel Echogenci drug-immunoliposomes for drug deliver. Invest Radiol 2004;39;104-110.
Unger EC, Porter T, Culp W, Labell R, Matsunaga T, Zutshi R. Therapeutic applications of lipid-coated microbubbles. Advanced Drug Delivery Reviews 2004;56:1291-1314.
Price RJ, Kaul S. Contrast ultrasound targeted drug and gene delivery; an update on a new therapeutic modalility. J Cardiovase Pharmacol Therapeuti 2002;7:171-180.
Tachibana K, Tachibana S. Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis. Circulation 1995;95:1148-50.
Villanueva FS, Jankowski RJ, Klibanov S, Pina ML, Alber SM, Watkins SC, Brandenburger GH, Wagner WR, Microbubbles targeted to intercellular adhesion molecule-I bind to activated coronary artery endothelial cells. Circulation 1998;98;1-5.
VisualSonics Vevo 770 Ultrasound. Cell and Tissue Analysis Core. http://ctac.mbi.ufl.edu/VisSon.htm.
Mitragotri, S. Healing Sound: The Use of Ultrasound in Drug Delivery and Other Therapeutic Applications. Nature Reviews. Mar. 2005. vol. 4. pp. 255-260.
Hood Elizabeth
Strom Joel A.
VanAuker Michael
Hartley Michael G
Lawson Michele L.
Samala Jagadishwar R
Smith & Hopen , P.A.
University of South Florida
LandOfFree
Ultrasound enhancement of drug release across non-ionic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ultrasound enhancement of drug release across non-ionic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ultrasound enhancement of drug release across non-ionic... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2734698