Ultrasound enchancement of membrane permeability

Details Ultrasound enchancement of membrane permeability Ultrasound enchancement of membrane permeability

1987-07-31

1988-10-25

Sever, Frank

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

204152, 210651, 210652, 210748, B01D 1300

Patent

active

047802120

ABSTRACT:
A method for enhancing or controlling permeability of large molecular weight molecules in a membrane system wherein molecules in solution are contacted with membranes and the system is exposed to ultrasound at a selected intensity and frequency and for a specific length of time. The method may be designed to insure that only reversible changes in the membrane result from exposure to the ultrasound or to enhance the rate of degradation of the membrane and/or selectivity of passage of molecules through the membrane. The method may include selection of the membrane composition and structure, including the pore size, thickness, crystallinity and molecular arrangement. Selection of the solvent or media in which the molecules are suspended may be used to further enhance or control permeability. The media may be either an aqueous or inorganic solution with the physical and chemical properties may be selected to attenuate sound transmission or to enhance stability of the molecule permeating the membrane.

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Lenart, et al., Ultrasonics 216-218 (Sep. 1980).
J. Lehmann, et al., "Uber die Wirkung von Ultraschall-Wellen auf den Ionendurchtritt durch biologische Membranen als Beitrag zur Theorie des therapeutischen Wirkungsmechanismus", 311-318.
Skauen and Zentner, Int. Journal Pharmaceutics 20, 235-245 (1984).
Brochure on the Sonopuls 434 ultrasound therapeutic apparatus.

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