Ultrasound contrast agents and methods of making and using them

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S009500, C424S009510

Reexamination Certificate

active

07083778

ABSTRACT:
Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.

REFERENCES:
patent: 3615972 (1971-10-01), Morehouse, Jr. et al.
patent: 3650831 (1972-03-01), Jungermann
patent: 3900420 (1975-08-01), Sebba
patent: 3968203 (1976-07-01), Spitzer
patent: 4027007 (1977-05-01), Messina
patent: 4192859 (1980-03-01), Mackaness et al.
patent: 4224179 (1980-09-01), Schneider
patent: 4229360 (1980-10-01), Schneider
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4265251 (1981-05-01), Tickner
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4316391 (1982-02-01), Tickner
patent: 4370349 (1983-01-01), Evans
patent: 4442843 (1984-04-01), Rasor
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4544545 (1985-10-01), Ryan
patent: 4572203 (1986-02-01), Feinstein
patent: 4657756 (1987-04-01), Rasor
patent: 4681119 (1987-07-01), Rasor
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4718433 (1988-01-01), Feinstein
patent: 4774958 (1988-10-01), Feinstein
patent: 4832941 (1989-05-01), Berwing
patent: 4844882 (1989-07-01), Widder et al.
patent: 4859363 (1989-08-01), Davis
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4927623 (1990-05-01), Long
patent: 4957656 (1990-09-01), Cerny
patent: 5049322 (1991-09-01), Devissaguet et al.
patent: 5088499 (1992-02-01), Unger
patent: 5089181 (1992-02-01), Hauser
patent: 5123414 (1992-06-01), Unger
patent: 5137928 (1992-08-01), Erbel
patent: 5141738 (1992-08-01), Rasor
patent: 5147631 (1992-09-01), Glajch et al.
patent: 5149319 (1992-09-01), Unger
patent: 5190982 (1993-03-01), Erbel
patent: 5195520 (1993-03-01), Schlief
patent: 5205287 (1993-04-01), Erbel
patent: 5209720 (1993-05-01), Unger
patent: 5271928 (1993-12-01), Schneider
patent: 5283067 (1994-02-01), Geller
patent: 5312615 (1994-05-01), Schneider
patent: 5352436 (1994-10-01), Wheatley
patent: 5364612 (1994-11-01), Goldenberg
patent: 5380411 (1995-01-01), Schlief
patent: 5380519 (1995-01-01), Schneider
patent: 5393524 (1995-02-01), Quay
patent: 5409688 (1995-04-01), Quay
patent: 5413774 (1995-05-01), Schneider
patent: 5425366 (1995-06-01), Reinhardt
patent: 5445813 (1995-08-01), Schneider
patent: 5501863 (1996-03-01), Rössling et al.
patent: 5529766 (1996-06-01), Klaveness
patent: 5531980 (1996-07-01), Schneider
patent: 5536489 (1996-07-01), Lohrmann
patent: 5536490 (1996-07-01), Klaveness
patent: 5542935 (1996-08-01), Unger et al.
patent: 5552133 (1996-09-01), Lambert et al.
patent: 5556610 (1996-09-01), Yan et al.
patent: 5558856 (1996-09-01), Klaveness et al.
patent: 5567413 (1996-10-01), Klaveness
patent: 5567414 (1996-10-01), Schneider
patent: 5593687 (1997-01-01), Rössling et al.
patent: 5599523 (1997-02-01), Beller
patent: 5601085 (1997-02-01), Østensen
patent: 5639443 (1997-06-01), Schutt et al.
patent: 5643553 (1997-07-01), Schneider
patent: 5658551 (1997-08-01), Schneider
patent: 5670135 (1997-09-01), Schroder
patent: 5711933 (1998-01-01), Bichon et al.
patent: 5716597 (1998-02-01), Lohrmann et al.
patent: 5730954 (1998-03-01), Albayrak et al.
patent: 5776429 (1998-07-01), Unger et al.
patent: 5874062 (1999-02-01), Unger
patent: 1232837 (1988-02-01), None
patent: 1239092 (1988-07-01), None
patent: 2077383 (1993-03-01), None
patent: A 41 27 442 (1993-02-01), None
patent: A 131 540 (1985-01-01), None
patent: A 324 938 (1989-07-01), None
patent: 359 246 (1990-03-01), None
patent: 359 246 (1990-03-01), None
patent: A 458 745 (1991-11-01), None
patent: A 554 213 (1993-04-01), None
patent: 1044680 (1966-10-01), None
patent: 213 5647 (1984-09-01), None
patent: 253115 (1996-01-01), None
patent: WO-A-80/2365 (1980-11-01), None
patent: WO 84/02838 (1984-08-01), None
patent: WO-A-85/02772 (1985-07-01), None
patent: WO 88/7365 (1988-10-01), None
patent: WO 89/05160 (1989-06-01), None
patent: WO 91/09629 (1991-07-01), None
patent: WO 91/12823 (1991-09-01), None
patent: WO 91/15244 (1991-10-01), None
patent: WO 92/05806 (1992-04-01), None
patent: WO 92/17213 (1992-10-01), None
patent: WO 92/17514 (1992-10-01), None
patent: WO 92/18164 (1992-10-01), None
patent: WO A 92/17212 (1992-10-01), None
patent: WO 92/19273 (1992-11-01), None
patent: WO 92/21382 (1992-12-01), None
patent: WO 92/22247 (1992-12-01), None
patent: WO 93/5819 (1993-04-01), None
patent: WO 93/06869 (1993-04-01), None
patent: WO 94/16739 (1994-04-01), None
patent: 910961 (1991-11-01), None
Biochemistry/Ed. Stryer—2 Ed., San Francisco, Freeman, pp. 208-209 (1981).
Concise Encyclopedia Of Polymer Sci. and Engin., Wiley, pp. 12-13 (1990).
Encyclopedia of Polymer Science and Engineering, 2nd ed., 10, p. 95, Wiley & Sons, 1987).
Encyclopedia of Polymer Science and Engineering, pp. 164-169, Wiley & Sons, 1985.
““Freon” Fluorocarbons Properties and Applications,”DuPont Technical Bulletin, pp. 1-11 (1964).
“Freon”DuPont Technical Bulletin, pp. 1-10 (1987).
Gas Encyclopedia, Elsevier Publishier (1976), CCIF3.
Handbook of Pharmaceutical Excipients: Am. Pharm. Ass. 181-183 (1986).
“Lecithin” in Rompp Chemie Kexikon, p. 2474 (1989-92).
“Lecithin” in Blakiston's Gould Medical Dictionary, 4th Ed., N.Y., Mcgraw-Hill,, p. 749 (1979).
“Lecithin” in Dorland's Illustrated Medical Dictionary, 26 Ed., Philadelphia, Saunders, p. 721 (1981).
Remington's Pharmaceutical Sciences: Mack Publ. Comp., 295-298: 736; 1242-44 (1975).
Barnhart et al.,Invest. Radiol, 25, 162-164 (1990) “Characterics of Albunex”.
Benita et al.,Journal of Pharmaceutical Science, 73, pp. 1721-1724 (1984) “Characterization of Drug Loaded Polydilactide Microspheres”.
Bleeker, et al.,J. Acoust. Soc. Am., 87 (4), Apr. 1990, pp. 1792-1797, “Ultrasonic characterization of Albunex® . . . ”.
Bleeker, et al., 1990J. Ultrasound Med., 9:461-471, (1999), “On the Application of Ultrasonic Contrast Agents . . . ”.
Bommer et al., Abstract of the 54 Scient. Sessions, Circulation 64,—203, Abst. 770 (1981).
Crommelin et al., Pharm. Res., pp. 159-163 (1984) “Stability of Liposomes on Storage . . . ”.
Crommelin et al., Liposomes as Drugs Carriers Symp., pp. 88-93 (1986) “Freezing and Freeze Drying of Liposomes”.
De Gruyter, “Phospholipids”,Concise Encyclopedia of Biochemistry, Berlin, pp. 348-349 (1983).
DeJong, et al.,Ultrasonics, 1992, vol. 30, No. 2, pp. 95-103, “Absorption and scatter of encapsulated gas filled microspheres . . . ”.
DeJong, et al.,Ultrasonics, 1991, vol. 29 Jul., pp. 324-330, “Principles and recent developments in ultrasound”.
Edwards, et al.J. Acoust. Soc. Am., vol. 70, No. 3 (1983), “Scattering of focused ultrasound by spherical microparticles”.
Epstein, et al.,J. Chem. Physics, vol. 18, No. 11, pp. 1505-1509, Nov. 1950, “On the Stability of Gas Bubbles in Liquid-Gas Solutions”.
Feinstein, et al.,JACC, vol. 16, No. 2, Aug. 1990:316-24, “Safety and Efficacy of a New Transpulmonary Ultrasound Agent . . . ”,Amer. Hearts Assn. Monograph Circulation, Part II, vol. 72, No. 4, Oct. 1985,Abstracts of the 58thScientific Ses.
Feinstein, et al.,Am. J. of Physiologic Imaging, 1:12-18 (1986), “Myocardial Contrast Echocardiography . . . ”.
Feinstein,J. of the Amer. Coll. of Cardiol, 8:251-253 (1986) “Myocardial Perfusion Imaging . . . ”

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Ultrasound contrast agents and methods of making and using them does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ultrasound contrast agents and methods of making and using them, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ultrasound contrast agents and methods of making and using them will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3660600

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.