Ultrasound contrast agents and methods of making and using them

Details Ultrasound contrast agents and methods of making and using them Ultrasound contrast agents and methods of making and using them

2006-08-01

2006-08-01

Jones, Dameron L. (Department: 1618)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

C424S009500, C424S009510

Reexamination Certificate

active

07083778

ABSTRACT:
Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.

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