Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Reexamination Certificate
2008-05-20
2008-05-20
Hartley, Michael G (Department: 1618)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
C424S009500
Reexamination Certificate
active
10798486
ABSTRACT:
New ultrasound contrast agents that comprise microbubbles encapsulating a gas within a shell made from a blend of bipolar compounds having mixed carbon chain length. The compounds have hydrophobic groups selected from the group consisting of straight-chained alkyls, alkylethers, alkylthiolethers, alkyldisulfides, polyfluoroalkyls, and polyfluoroalkylethers having a carbon chain length greater than or equal to 16 and less than or equal to 32. The polar groups are connected to the hydrophobic groups by means of a linker. The polar head groups are selected from the group consisting of CO2-M+, SO3−M+, SO4−M+, PO3−M+, PO4−M+2, N(R)4+, a pyridinium or substituted pyridinium group, and a zwitterionic group; R is selected from the group consisting of —H, —CH3, alkyl, cycloalkyl, substituted cycloalkyls containing one or more heteroatoms, and benzyl and can be the same or different; and Z′ is a nonionic and M is a cation.
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Hartley Michael G
Mallinckrodt Inc.
Schlientz Leah
Thompson Hine LLP
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