Ultrasonic transdermal system for withdrawing fluid from an orga

Details Ultrasonic transdermal system for withdrawing fluid from an orga Ultrasonic transdermal system for withdrawing fluid from an orga

1995-03-14

1997-04-08

Sykes, Angela D.

Surgery

Truss

Pad

128635, 128760, 128766, A61B 500

Patent

active

056178514

ABSTRACT:
A noninvasive method and apparatus for withdrawing fluid from an organism and determining the concentration of a substance in the fluid is disclosed. The noninvasive apparatus comprises a substance concentration sensor (120) that includes an extraction transducer (126) and a substance sensing transducer (133). The extraction transducer includes a container (123); a planar piezoelectric (ultrasonic) transducer (124); a focusing lens (125); and a backing layer (127). The container includes a flange (129) that is attached to the skin of an organism by an adhesive film seal (131). The focusing lens (125) is a plano-concave shape such that the concave side faces the skin of the organism. Thus, the focusing lens (125) defines a cavity (135). Located in the cavity (135) is the substance sensing transducer (133). Positioned above the focusing lens is the ultrasonic transducer (124). A pulse generator (121) is connected to and drives the ultrasonic transducer. A test data processor (122) is connected to the substance sensing transducer (133). Ultrasonic transducer pulses are focused by the focusing lens (125) into the organism, traumatizing the skin underlying the cavity (135). The trauma causes the dermal-epidermal junction membrane and the capillary endothelial joints to open and allow fluid to be drawn from the cavity (135). The substance to be detected in the fluid is sensed by the substance sensing transducer (133) causing the output of the transducer to change. The output changes are analyzed by the test data processor (122).

REFERENCES:
patent: 4029084 (1977-06-01), Soldner
patent: 4309989 (1982-01-01), Fahim
patent: 4372296 (1983-02-01), Fahim
patent: 4542751 (1985-09-01), Webster et al.
patent: 4657022 (1987-04-01), Holscher
patent: 4657543 (1987-04-01), Langer et al.
patent: 4706676 (1987-11-01), Peck
patent: 4756314 (1988-07-01), Eckenhoff et al.
patent: 4767402 (1988-08-01), Kost et al.
patent: 4780212 (1988-10-01), Kost et al.
patent: 4787888 (1988-11-01), Fox
patent: 4821733 (1989-04-01), Peck
patent: 4821740 (1989-04-01), Tachibana et al.
patent: 4948587 (1990-08-01), Kost et al.
patent: 4953552 (1990-09-01), Demarzo
patent: 4953565 (1990-09-01), Tachibana et al.
patent: 5007438 (1991-04-01), Tachibana et al.
patent: 5016615 (1991-05-01), Driller et al.
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5036861 (1991-08-01), Sembrowich et al.
patent: 5053001 (1991-10-01), Reller
patent: 5076273 (1991-12-01), Schoendorfer et al.
patent: 5080646 (1992-01-01), Theeuwes et al.
patent: 5084008 (1992-01-01), Phipps
patent: 5115805 (1992-05-01), Bommannan et al.
patent: 5131403 (1992-07-01), Haynes
patent: 5135478 (1992-08-01), Sibalis
patent: 5139023 (1992-08-01), Stanley et al.
patent: 5171215 (1992-12-01), Flanagan
patent: 5231975 (1993-08-01), Bommannan et al.
patent: 5236414 (1993-08-01), Takasu
patent: 5267985 (1993-12-01), Shimada et al.
patent: 5291887 (1994-03-01), Stanley et al.
patent: 5323769 (1994-06-01), Bommannan et al.
Donald M. Skauen et al., "Phonophoresis," International Journal of Pharmaceutics, 20 (1984), pp. 235-245.
Katsuro Tachibana, "Transdermal Delivery of Insulin to Alloxan-Diabetic Rabbits by Ulatrasound Exposure," Pharmaceutical Research, vol. 19, No. 7, 1992, pp. 109-111.
D. Bommannan et al., "Sonophoresis. I. The Use of High-Frequency Ultrasound to Enhance Transdermal Drug Delivery," Pharmaceutical Research, vol. 9, No. 4, 1992, pp. 559-564.
D. Bommannan et al., "Sonophoresis. II. Examination of the Mechanism(s) of Ultrasound-Enhanced Transdermal Drug Delivery," Pharmaceutical Research, vol. 9, No. 8, 1992, pp. 1043-1047.
J.C. McElnay et al., "The Influence of ultrasound on the percutaneous absorption of fluocinolone acetonide," International Journal of Pharmaceutics, 40 (1987), pp. 105-110.
Motoaki Shichiri et al., "Wearable Artificial Endocrine Pancreas with Needle-type Glucose Sensor," The Lancet, Nov. 20, 1982, pp. 1129-1131.
Deborah Erickson, "Skinside Out," Scientific American, Nov. 1991, pp. 129-130.
Joseph Kost, "Ultrasound induced delivery of peptides," Journal of Controlled Release, 24 (1993), pp. 247-255.

Affiliated with

Also associated with

Rating

Ultrasonic transdermal system for withdrawing fluid from an orga does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ultrasonic transdermal system for withdrawing fluid from an orga, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ultrasonic transdermal system for withdrawing fluid from an orga will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2392758