Ultrasonic transdermal application of steroid compositions

Details Ultrasonic transdermal application of steroid compositions Ultrasonic transdermal application of steroid compositions

1988-04-27

1989-09-12

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514180, A61K 3156

Patent

active

048660507

ABSTRACT:
A dexamethasone delivery composition includes dexamethasone disposed in a cellulosic gel, preferably a hydroxycellulose gel. Lidocaine solubilizes the dexamethasone into the gel to provide a dexamethasone composition of increased concentration and enhanced tissue penetration capability. A method for the transdermal delivery of dexamethasone includes the step of applying the dexamethasone gel composition of the invention to the tissue of a patient and applying ultrasound at the site to effect penetration of the dexamethasone.

REFERENCES:
patent: 3007923 (1961-11-01), Muller et al.
patent: 3962430 (1976-06-01), O'Neill
patent: 4440777 (1984-04-01), Zupan
patent: 4482539 (1984-11-01), Sandweiss et al.
patent: 4701451 (1987-10-01), Annen et al.
patent: 4710497 (1981-12-01), Heller et al.

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