Ultrasonic coagulation timer

Details Ultrasonic coagulation timer Ultrasonic coagulation timer

1975-04-25

1977-03-29

Queisser, Richard C.

Chemistry: physical processes

Physical processes

Crystallization

23253R, 73 641, G01N 3316

Patent

active

040146502

ABSTRACT:
A system for measuring the coagulation time of plasma or whole blood. A solution containing the blood sample is irradiated with pulsed ultrasound, and the back-scattered ultrasound is continuously measured. A predetermined quantity of thrombin is then added to the solution, causing the amplitude of the backscattered ultrasound to fluctuate until coagulation occurs. The elapsed time between the addition of thrombin and the inception of coagulation is the coagulation time, and is an indication of the concentration of fibrinogen in the blood sample.

REFERENCES:
patent: 3040562 (1962-06-01), Fitzgerald et al.
patent: 3520659 (1970-07-01), Steinberg et al.
patent: 3553636 (1971-01-01), Baird
patent: 3572099 (1971-03-01), Wieczorek
patent: 3654072 (1972-04-01), Massa
patent: 3658480 (1972-04-01), Kane et al.
patent: 3710615 (1973-01-01), Johnson et al.
patent: 3791200 (1974-02-01), Hayre

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