Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1997-03-20
1998-10-06
Mendez, Manuel
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
604 22, A61N 130
Patent
active
058170480
ABSTRACT:
Disclosed is a method for activating photosensitive therapeutic and other compounds, comprising the steps of (a) providing a photosensitive therapeutic compound in combination with an appropriate solvent, such as dimethyl phthalate (DMP); (b) generating acoustic energy for generating free radicals from the solvent and reacting the free radicals with an oxalate ester to generate a key intermediate; (c) transferring chemical energy to the photosensitive therapeutic compound from the key intermediate; and (d) activating the photosensitive compound with the transferred energy. In an illustrative embodiment of this invention the oxalate ester is comprised of ester bis (2,4-dinitrophenyl) oxalate (DNPO). Also disclosed is a method for enhancing the effectiveness of photodynamic therapy by also generating acoustic energy to increase selectivity and/or increase the numbers of free radicals. In addition, an ultrasound-based therapy is described which uses a selectively retained or absorbed chemical species in conjunction with existing O.sub.2 in the body to create reactive species such as H.sub.2 O.sub.2 with ultrasonic excitation. It is also within the scope of this invention to increase the oxygen level of the blood stream and tissue prior to and during treatment, such as by using an ultrasound contrast agent.
Brown University Research Foundation
Mendez Manuel
LandOfFree
Ultrasonic alternative to laser-based photodynamic therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ultrasonic alternative to laser-based photodynamic therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ultrasonic alternative to laser-based photodynamic therapy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-73112