Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-02-06
1998-07-07
Kumar, Shailendra
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
1286622, 210639, 210709, 210729, 423495, 424 95, 424 951, 424 952, 424490, 424491, 424495, 514410, 514951, 514965, 560 45, 562455, A61K 914
Patent
active
057764964
ABSTRACT:
This invention relates to the preparation, composition and applications of suspensions of ultra-small, substantially non-aggregated, non-crystalline particles of predetermined uniform size which, when suspended in a liquid, contain entrapped gaseous bubbles. These gaseous bubble particles are prepared by simultaneous co-precipitation of two compounds. In accordance with the present invention, the two compounds chosen for co-precipitation are such that one is substantially more soluble than the other in a given vehicle. When this vehicle is used for washing the co-precipitated particles, part of the soluble material is dissolved leaving a porous matrix. The porous particles then are dried and stored. The porous particles, which can be resuspended immediately prior to use, contain entrapped gas in the evacuated crevices or pores which is not displaced for a period of time because of surface tension of the suspending vehicle. These ultrasmall, substantially non-aggregated porous particles therefore can be used to advantage as ultrasound contrast agents as well as other applications.
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Parker Kevin J.
Violante Michael R.
Kumar Shailendra
University of Rochester
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