Ultrashort-acting opioids for transdermal application

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S223000, C546S224000

Reexamination Certificate

active

07381735

ABSTRACT:
The subject invention concerns analogs of fentanyl opioids. The subject invention also concerns methods for synthesizing the compounds of the invention. The invention also concerns methods for treating pain in a patient by administering a compound of the invention to a person in need of such treatment.

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Sebastiano et al, Journal of Pain and symptom Management, vol. 21 No. 3 Feb. 2001 pp. 144-150.
Feldman, P. et al., “Design, Synthesis, and Pharmacological Evaluation of Ultrashort-to-Long-Acting Opiod Analgesics”,Journal of Medicinal Chemistry, 1991, vol. 34, No. 7, pp. 2202-2208.
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Lutz, M. et al., “A pharmacodynamic Model To Investigate The Structure-Activity Profile of A Series of Novel Opioid Analgesics”,Journal of Pharmacology and Experimental Therapeutics, 1994, vol. 271, No. 2, pp. 795-803, abstract only.
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