Ultrapurification of factor VIII using monoclonal antibodies

Details Ultrapurification of factor VIII using monoclonal antibodies Ultrapurification of factor VIII using monoclonal antibodies

1981-12-14

1982-11-30

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, 424 85, C07G 700

Patent

active

043615090

ABSTRACT:
A method of preparing high purity procoagulant protein comprising the steps of (a) adsorbing a VIII:C/VIII:RP complex from a plasma or commercial concentrate source of factor VIII onto agarose beads bound to a monoclonal antibody specific to VIII:RP, (b) eluting VIII:C with a salt solution, (c) adsorbing the eluted VIII:C on an animohexyl agarose column and eluting the VIII:C with a salt solution.

REFERENCES:
patent: 3631018 (1971-12-01), Shanbrom et al.
patent: 3652530 (1972-03-01), Johnson et al.
patent: 3682881 (1972-08-01), Fekete et al.
patent: 4069216 (1978-01-01), Shanbrom
patent: 4137223 (1979-01-01), Shanbrom et al.
patent: 4188318 (1980-02-01), Shanbrom
patent: 4203891 (1980-05-01), Rock
J. of Lab. Clin. Med., vol. 93, p. 40, (1979), Tuddenham et al.

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