Ultrapure hyaluronic acid and method of making it

Details Ultrapure hyaluronic acid and method of making it Ultrapure hyaluronic acid and method of making it

1986-09-18

1988-11-01

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 551, C08B 3708, A61K 31725

Patent

active

047820462

ABSTRACT:
Hyaluronic acid having controlled molecular weight and substantially free of protein and nucleic acids can be prepared from a hyaluronidase-negative or hyaluronidase inhibited microbiological source. Product may be used as replacement fluid in mammals.

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patent: 4328803 (1982-05-01), Pape
Infection and Immunity, Feb. 1980, vol. 27, No. 2, pp. 444-448, "Growth Characteristics of Group A Streptococci in a New Chemically Defined Medium".
J. Gen. Microbiol., 1974, 85, Pt. 2, 372-5, "The Capsule of Streptococcus equi", (Abstract No. 121419v also enclosed).
Acta. Path. Microbiol. Scand., Sect. B, 84, 162-164, 1976, "Isolation of Hyaluronic Acid from Cultures of Streptococci in a Chemically Defined Medium", (CA 85:16770s, vol. 85, 1976 also enclosed).
Merck Index, 9th Ed., (3rd Printing), 1978, p. 537.
Arch. Ophthal--Vol. 88, (1972), pp. 544-548, David S. Swann.

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